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14 Jul 2021 BMRC Institute of Molecular and Cell Biology CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity Ying Yu Liang, Smaranda Bacanu, Lekshmy Sreekumar, Anderson Daniel Ramos, Lingyun Dai, Martin Michaelis, Jindrich Cinatl, Takahiro Seki, Yihai Cao, Cynthia R. Coffill, David P. Lane, Nayana Prabhu, Pär Nordlund Cell Chemical Biology
11 May 2020 BMRC Bioinformatics Institute Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan, Arun Chandramohan, Yi Han, Jin Huei Wong, Yaw Sing Tan, Zi Wei Chang, Fernando Jose Ferrer-Gago, Prakash Arumugam, Shiying Chen, Laurent Claude Stephane Renia, Christopher J. Brown, Charles W. Johannes, Brian Henry, David P. Lane, Tomi K Sawyer, Chandra S. Verma, Anthony William Patridge Chemical Science
5 May 2020 BMRC Bioinformatics Institute De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits Simon Ng, Yu-Chi Juang, Arun Chandramohan, Hung Yi Kristal Kaan, Ahmad Sadruddin, Tsz Ying Yuen, Fernando J. Ferrer-Gago, Xue'Er Cheryl Lee, Liew Xi, Charles W. Johanes, Christopher J. Brown, Srinivasaraghavan Kanan, Pietro G. Aronica, Nils A. Berglund, Chandra S. Verma, Lijuan Liu, Alexander Stoeck, Tomi K. Sawyer, Anthony W. Partridge, David P. Lane ACS Medicinal Chemistry Letters
29 Apr 2020 BMRC Bioinformatics Institute Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation Li Ren Kong, Richard Weijie Ong, Tua Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, Miyoung Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Chwee Ming Lim, Wee Joo Chng, David P. Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh Nature Communications
19 Apr 2020 BMRC p53 Laboratory Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks Sara Lundsten, Víctor Agmo Hernández, Lars Gedda, Tina Sarén, Christopher J. Brown, David P. Lane, Katarina Edwards, Marika Nestor Nanomaterials
16 Apr 2020 BMRC p53 Laboratory Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2 Anja C. L. Mortensen, Eric Morin, Christopher J. Brown, David P. Lane, Marika Nestor EJNMMI Research
2 Mar 2020 BMRC p53 Laboratory bioPROTACs as Versatile Modulators of Intracellular Therapeutic Targets Including Proliferating Cell Nuclear Antigen (PCNA) Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, Anthony W. Patridge Proceedings of the National Academy of Sciences of the United States of America
1 Dec 2019 BMRC p53 Laboratory High Intracellular Stability of the Spidroin N-terminal Domain in Spite of Abundant Amyloidogenic Segments Revealed by In-Cell Hydrogen/Deuterium Exchange Mass Spectrometry Margit Kaldmäe, Axel Leppert, Gefei Chen, Medoune Sarr, Cagla Sahin, Kerstin Nordling, Nina Kronqvist, Marta Gonzalvo-Ulla, Nicolas Fritz, Axel Abelein, Sonia Laίn, Henrik Biverstal, Hans Jornvall, David P. Lane, Anna Rising, Jan Johansson, Michael Landreh The FEBS Journal
28 Nov 2019 BMRC Bioinformatics Institute The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors Srinivasaraghavan Kannan, Anthony W. Partridge, David P. Lane, Chandra S. Verma International Journal of Molecular Sciences
15 Aug 2019 BMRC Bioinformatics Institute Therapeutic anti-cancer activity of antibodies targeting sulfhydryl bond constrained epitopes on unglycosylated RON receptor tyrosine kinase Le-Ann Hwang, Fernando Jose Ferrer, Xin Yu Koh, Xiao Hui Koh, Sit Aishah Binte Rahmat, Dilray Lama, David P. Lane Oncogene