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11 May 2020 BMRC Bioinformatics Institute Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan, Arun Chandramohan, Yi Han, Jin Huei Wong, Yaw Sing Tan, Zi Wei Chang, Fernando Jose Ferrer-Gago, Prakash Arumugam, Shiying Chen, Laurent Claude Stephane Renia, Christopher J. Brown, Charles W. Johannes, Brian Henry, David P. Lane, Tomi K Sawyer, Chandra S. Verma, Anthony William Patridge
5 May 2020 BMRC Bioinformatics Institute De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits Simon Ng, Yu-Chi Juang, Arun Chandramohan, Hung Yi Kristal Kaan, Ahmad Sadruddin, Tsz Ying Yuen, Fernando J. Ferrer-Gago, Xue'Er Cheryl Lee, Liew Xi, Charles W. Johanes, Christopher J. Brown, Srinivasaraghavan Kanan, Pietro G. Aronica, Nils A. Berglund, Chandra S. Verma, Lijuan Liu, Alexander Stoeck, Tomi K. Sawyer, Anthony W. Partridge, David P. Lane
29 Apr 2020 BMRC Bioinformatics Institute Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation Li Ren Kong, Richard Weijie Ong, Tua Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, Miyoung Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Chwee Ming Lim, Wee Joo Chng, David P. Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh
19 Apr 2020 BMRC p53 Laboratory Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks Sara Lundsten, Víctor Agmo Hernández, Lars Gedda, Tina Sarén, Christopher J. Brown, David P. Lane, Katarina Edwards, Marika Nestor
16 Apr 2020 BMRC p53 Laboratory Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2 Anja C. L. Mortensen, Eric Morin, Christopher J. Brown, David P. Lane, Marika Nestor
2 Mar 2020 BMRC p53 Laboratory bioPROTACs as Versatile Modulators of Intracellular Therapeutic Targets Including Proliferating Cell Nuclear Antigen (PCNA) Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, Anthony W. Patridge
1 Dec 2019 BMRC p53 Laboratory High Intracellular Stability of the Spidroin N-terminal Domain in Spite of Abundant Amyloidogenic Segments Revealed by In-Cell Hydrogen/Deuterium Exchange Mass Spectrometry Margit Kaldmäe, Axel Leppert, Gefei Chen, Medoune Sarr, Cagla Sahin, Kerstin Nordling, Nina Kronqvist, Marta Gonzalvo-Ulla, Nicolas Fritz, Axel Abelein, Sonia Laίn, Henrik Biverstal, Hans Jornvall, David P. Lane, Anna Rising, Jan Johansson, Michael Landreh
28 Nov 2019 BMRC Bioinformatics Institute The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors Srinivasaraghavan Kannan, Anthony W. Partridge, David P. Lane, Chandra S. Verma
15 Aug 2019 BMRC Bioinformatics Institute Therapeutic anti-cancer activity of antibodies targeting sulfhydryl bond constrained epitopes on unglycosylated RON receptor tyrosine kinase Le-Ann Hwang, Fernando Jose Ferrer, Xin Yu Koh, Xiao Hui Koh, Sit Aishah Binte Rahmat, Dilray Lama, David P. Lane
20 Jun 2019 BMRC Bioinformatics Institute Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties Anthony W. Patridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Praddhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherbone, David P. Lane, Tomi K. Sawyer
30 May 2019 BMRC Bioinformatics Institute Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles A. Johannes
30 May 2019 BMRC p53 Laboratory Stereoisomerism of Stapled Peptide Inhibitors of the p53-Mdm2 Interaction: An Assessment of Synthetic Strategies and Activity Profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes
30 May 2019 SERC Institute of Chemical and Engineering Sciences Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes
29 May 2019 BMRC Bioinformatics Institute Characterization of Hydration Properties in Structural Ensembles of Biomolecules Mohan R. Pradhan, Minh N. Nguyen, Srinivasaraghavan Kannan, Stephen J. Fox, Chee Keong Kwoh, David P. Lane, Chandra S. Verma
28 May 2019 BMRC Institute of Medical Biology Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo Nick Barker, Shawn Hoon, Yuezhen Xue, Pingping He, Teena Thakur, Shifana Raja Abdeen, Priadarsini Maruthappan, Farid J. Ghadessy, David P. Lane
22 May 2019 BMRC p53 Laboratory Monitoring Flux in Signalling Pathways Through Measurements of 4EBP1-mediated eIF4F Complex Assembly Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane, Christopher J. Brown
29 Apr 2019 BMRC p53 Laboratory p53: Updates on Mechanisms, Biology and Therapy (II) David P. Lane, Chandra S. Verma
23 Apr 2019 BMRC p53 Laboratory p53: Updates on Mechanisms, Biology and Therapy (I) David P. Lane, Chandra S. Verma
14 Apr 2019 BMRC p53 Laboratory Understanding p53 Functions Through p53 Antibodies Kanaga Sabapathy, David P. Lane
1 Mar 2019 BMRC p53 Laboratory SHON Expression Predicts Response and Relapse Risk of Breast Cancer Patients After Anthracycline-Based Combination Chemotherapy or Tamoxifen Treatment Longxin Chen, Runlin Z. Ma, Wenming Cao, Xiaojia Wang, Yan Li, Jo K. Perry, Mohammed Aleskandarany, Christopher C. Nolan, Emad A. Rakha, Peter E. Lobie, Stephen Y. T. Chan, Ian O. Ellis, Le-Ann Hwang, David P. Lane, Andrew R. Green, Dong-Xu Liu, Tarek M. A. Abdel-Fatah, Reuben J. Broom, Jun Lu, Paul M. Moseley, Baiqu Huang, Lili Li, Suling Liu
15 Jan 2019 BMRC Bioinformatics Institute Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket Mohan R. Pradhan, Jia Wei Siau, Srinivasaraghavan Kannan, Minh N. Nguyen, Zohra Ouaray, Chee Keong Kwoh, David P. Lane, Farid Ghadessy, Chandra S. Verma
7 Jan 2019 BMRC Bioinformatics Institute Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein Christopher J. Brown, Chandra Verma, Serge Auvin, Dilraj Lama, Anne-Marie Liberatore, Yuri Frosi, Jessica Nakhle, Natia Tsomaia, Tarig Bashir, David P. Lane
24 Sep 2018 BMRC p53 Laboratory Ultrasensitive dynamic light scattering based nanobiosensor for rapid anticancer drug screening Xin Ting Zheng, Walter L. Goh, Peter Yeow, David P. Lane, Farid J. Ghadessy, Yen Nee Tan
19 Jul 2018 BMRC p53 Laboratory The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors Diana Spiegelberg, Anja C. Mortensen, Sara Lundsten, Christopher J. Brown, David P. Lane, Marika Nestor
16 Mar 2018 BMRC p53 Laboratory A DHODH Inhibitor Increases p53 Synthesis and Enhances Tumor Cell Killing by p53 Degradation Blockage Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Mihaela Popa, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D'Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Lain
15 Mar 2018 BMRC p53 Laboratory Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase Joana Costeira-Paulo, Joseph Gault, Gergana Popova, Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Medoune Sarr, Anders Olsson, David P. Lane, Sonia Lain, Erik G. Marklund, Michael Landreh
2 Jan 2018 BMRC p53 Laboratory Monoclonal Antibodies Against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy
1 Dec 2017 BMRC p53 Laboratory Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53 Jane Vin Chan, Dawn Xin Ping Koh, Yun Liu, Thomas L. Joseph, David P. Lane, Chandra S. Verma, Yaw Sing Tan
15 Nov 2017 BMRC p53 Laboratory Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations Shilpa Yadahalli, Jianguo Li, David P. Lane, Shachi Gosavi, Chandra S. Verma
10 Nov 2017 BMRC p53 Laboratory Evidence for allosteric effects on p53 oligomerization induced by phosphorylation Petr Muller, Juliana M. Chan, Oliver Simoncik, Miroslav Fojta, David P. Lane, Ted Hupp, Borivoj Vojtesek
9 Nov 2017 BMRC p53 Laboratory A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53 Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane, Prakash Arumugam
27 Jun 2017 BMRC p53 Laboratory Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity Shunsheng Zheng, Xin Yu Koh, Hui Chin Goh, Siti Aishah B. Rahmat, Le-Ann Hwang, David P. Lane
7 Feb 2017 BMRC p53 Laboratory Anatomy of Mdm2 and Mdm4 in evolution Ban Xiong Tan, Hoe Peng Liew, Joy S. Chua, Farid J. Ghadessy, Yaw Sing Tan, David P. Lane, Cynthia R. Coffill
3 Jan 2017 BMRC Bioinformatics Institute Water-Bridge Mediates Recognition of mRNA Cap in eIF4E Dilraj Lama, Mohan R. Pradhan, Christopher J. Brown, Rohan S. Eapen, Thomas L. Joseph, Chee-Keong Kwoh, David P. Lane, Chandra S. Verma
17 Aug 2016 BMRC Bioinformatics Institute Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design Yaw Sing Tan, Judith Reeks, Christopher J. Brown, Dawn Thean, Fernando Jose Ferrer Gago, Tsz Ying Yuen, Eunice Tze Leng Goh, Xue Er Cheryl Lee, Claire E. Jennings, Thomas L. Joseph, Rajamani Lakshminarayanan, David P. Lane, Martin E. M. Noble, Chandra S. Verma
31 Mar 2016 BMRC Bioinformatics Institute Long range recognition and selection in IDPs: the interactions of the C-terminus of p53 Srinivasaraghavan Kannan, David P. Lane, Chandra S. Verma
21 Jan 2016 BMRC Bioinformatics Institute The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans Cynthia R. Coffill, Alison P. Lee, Jia Wei Siau, Sharon M. Chee, Thomas L. Joseph, Yaw Sing Tan, Arumugam Madhumalar, Boon-Hui Tay, Sydney Brenner, Chandra S. Verma, Farid J. Ghadessy, Byrappa Venkatesh, David P. Lane
22 Jul 2015 BMRC Institute of Medical Biology Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice Amanda M. Goh, Yuezhen Xue, Marc Leushacke, Ling Li, Julin S. Wong, Poh Cheang Chiam, Siti Aishah Rahmat, Michael B. Mann, Karen M. Mann, Nick Barker, Guillermina Lozano, Tamara Terzian, David P. Lane
10 Jul 2015 BMRC p53 Laboratory Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays Ban Xiong Tan, Christopher J. Brown, Fernando J. Ferrer, Tze Ying Yuen, Soo Tng Quah, Boon Hong Chan, Anna E. Jansson, Hsiang Ling Teo, Pär Nordlund, David P. Lane
19 Jun 2015 BMRC p53 Laboratory A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells Junlong Geng, Walter L. Goh, Chongjing Zhang, David P. Lane, Bin Liu, Farid J. Ghadessy, Yen Nee Tan
20 Feb 2015 BMRC p53 Laboratory p53 Isoform Δ113p53/Δ133p53 Promotes DNA Double-Strand Break Repair to Protect Cell From Death and Senescence in Response to DNA Damage Lu Gong, Hongjian Gong, Xiao Pan, Changqing Chang, Zhao Ou, Shengfan Ye, Le Yin, Lina Yang, Ting Tao, Zhenhai Zhang, Cong Liu, David P. Lane, Jinrong Peng, Jun Chen
21 Aug 2014 BMRC p53 Laboratory Autophagic degradation of the inhibitory p53 isoform D133p53a as a regulatory mechanism for p53-mediated senescence Izumi Horikawa, Kaori Fujita, Lisa M. Miller Jenkins, Yukiharu Hiyoshi, Abdul M. Mondal, Borivoj Vojtesek, David P. Lane, Ettore Appella, Curtis C. Harris
9 Jun 2014 BMRC Institute of Molecular and Cell Biology Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging Yunhua Zhu, Oleg N. Demidov, Amanda M. Goh, David M. Virshup, David P. Lane, Dmitry V. Bulavin
10 Mar 2014 BMRC Bioinformatics Institute Functionalised staple linkages for modulating the cellular activity of stapled peptides Yu Heng Lau, Peterson de Andrade, Soo-Tng Quah, Maxim Rossmann, Luca Laraia, Niklas Skold, Tze Jing Sum, Pamela J.E. Rowling, Thomas L. Joseph, Chandra Verma, Marko Hyvonen, Laura S. Itzhaki, Ashok R. Venkitaraman, Christopher J. Brown, David P. Lane, David R. Spring
29 Jan 2014 BMRC p53 Laboratory The Fluorescent Two-Hybrid Assay to Screen for Protein–Protein Interaction Inhibitors in Live Cells: Targeting the Interaction of p53 with Mdm2 and Mdm4 Larisa Yurlova, Maarten Derks, Andrea Buchfellner, Ian Hickson, Marc Janssen, Denise Morrison, Ian Stansfield, Christopher J. Brown, Farid J. Ghadessy, David P. Lane, Ulrich Rothbauer, Kourosh Zolghadr, Eberhard Krausz
13 Dec 2013 BMRC Bioinformatics Institute Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces Dilraj Lama, Soo Tng Quah, Chandra Verma, Rajamani Lakshminarayanan, Roger Beuerman, David P. Lane, Christopher Brown
1 Dec 2013 BMRC Bioinformatics Institute A comparison and optimization of methods and factors affecting the transformation of Escherichia coli. Weng Tat Chan, Chandra Verma, David P. Lane, Samuel Gan
21 Nov 2013 BMRC p53 Laboratory On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein Karim ElSawy, Chandra S. Verma, David P. Lane, Leo Caves
20 Nov 2013 BMRC Bioinformatics Institute Inhibition of nutlin-resistant HDM2 mutants by stapled peptides Jia Wei Siau, Thomas Joseph, Sharon Chee, Ling Li, Larisa Yurlova, Kourosh Zolghadr, Christopher Brown, David P. Lane, Chandra Verma, Farid Ghadessy
12 Nov 2013 BMRC Bioinformatics Institute Mapping the Structural and Dynamical Features of Multiple p53 DNA Binding Domains: Insights into Loop 1 Intrinsic Dynamics Suryani Lukman, David P. Lane, Chandra Verma