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11 May 2020 BMRC Bioinformatics Institute Macrocyclization of an all-D linear α-helical peptide imparts cellular permeability Srinivasaraghavan Kannan, Pietro G. A. Aronica, Simon Ng, Dawn Thean Gek Lian, Yuri Frosi, Sharon Chee, Shimin Jiang, Tsz Ying Yuen, Ahmad Sadruddin, Hung Yi Kristal Kaan, Arun Chandramohan, Yi Han, Jin Huei Wong, Yaw Sing Tan, Zi Wei Chang, Fernando Jose Ferrer-Gago, Prakash Arumugam, Shiying Chen, Laurent Claude Stephane Renia, Christopher J. Brown, Charles W. Johannes, Brian Henry, David P. Lane, Tomi K Sawyer, Chandra S. Verma, Anthony William Patridge
5 May 2020 BMRC Bioinformatics Institute De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits Simon Ng, Yu-Chi Juang, Arun Chandramohan, Hung Yi Kristal Kaan, Ahmad Sadruddin, Tsz Ying Yuen, Fernando J. Ferrer-Gago, Xue'Er Cheryl Lee, Liew Xi, Charles W. Johanes, Christopher J. Brown, Srinivasaraghavan Kanan, Pietro G. Aronica, Nils A. Berglund, Chandra S. Verma, Lijuan Liu, Alexander Stoeck, Tomi K. Sawyer, Anthony W. Partridge, David P. Lane
19 Apr 2020 BMRC p53 Laboratory Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks Sara Lundsten, Víctor Agmo Hernández, Lars Gedda, Tina Sarén, Christopher J. Brown, David P. Lane, Katarina Edwards, Marika Nestor
16 Apr 2020 BMRC p53 Laboratory Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2 Anja C. L. Mortensen, Eric Morin, Christopher J. Brown, David P. Lane, Marika Nestor
2 Mar 2020 BMRC p53 Laboratory bioPROTACs as Versatile Modulators of Intracellular Therapeutic Targets Including Proliferating Cell Nuclear Antigen (PCNA) Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, Anthony W. Patridge
11 Dec 2019 SERC Institute of Chemical and Engineering Sciences Synthesis of chiral alkenyl cyclopropane amino acids for incorporation into stapled peptides Tsz Ying Yuen, Christopher J. Brown, Yaw Sing Tan, Charles W. Johannes
20 Jun 2019 BMRC Bioinformatics Institute Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties Anthony W. Patridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Praddhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherbone, David P. Lane, Tomi K. Sawyer
30 May 2019 BMRC Bioinformatics Institute Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles A. Johannes
30 May 2019 BMRC p53 Laboratory Stereoisomerism of Stapled Peptide Inhibitors of the p53-Mdm2 Interaction: An Assessment of Synthetic Strategies and Activity Profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes
30 May 2019 SERC Institute of Chemical and Engineering Sciences Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando J. Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge, Chandra S. Verma, David P. Lane, Charles W. Johannes
22 May 2019 BMRC p53 Laboratory Monitoring Flux in Signalling Pathways Through Measurements of 4EBP1-mediated eIF4F Complex Assembly Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane, Christopher J. Brown
7 Jan 2019 BMRC Bioinformatics Institute Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein Christopher J. Brown, Chandra Verma, Serge Auvin, Dilraj Lama, Anne-Marie Liberatore, Yuri Frosi, Jessica Nakhle, Natia Tsomaia, Tarig Bashir, David P. Lane
19 Jul 2018 BMRC p53 Laboratory The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors Diana Spiegelberg, Anja C. Mortensen, Sara Lundsten, Christopher J. Brown, David P. Lane, Marika Nestor
3 Jan 2017 BMRC Bioinformatics Institute Water-Bridge Mediates Recognition of mRNA Cap in eIF4E Dilraj Lama, Mohan R. Pradhan, Christopher J. Brown, Rohan S. Eapen, Thomas L. Joseph, Chee-Keong Kwoh, David P. Lane, Chandra S. Verma
17 Aug 2016 BMRC Bioinformatics Institute Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design Yaw Sing Tan, Judith Reeks, Christopher J. Brown, Dawn Thean, Fernando Jose Ferrer Gago, Tsz Ying Yuen, Eunice Tze Leng Goh, Xue Er Cheryl Lee, Claire E. Jennings, Thomas L. Joseph, Rajamani Lakshminarayanan, David P. Lane, Martin E. M. Noble, Chandra S. Verma
10 Jul 2015 BMRC p53 Laboratory Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays Ban Xiong Tan, Christopher J. Brown, Fernando J. Ferrer, Tze Ying Yuen, Soo Tng Quah, Boon Hong Chan, Anna E. Jansson, Hsiang Ling Teo, Pär Nordlund, David P. Lane
10 Mar 2014 BMRC Bioinformatics Institute Functionalised staple linkages for modulating the cellular activity of stapled peptides Yu Heng Lau, Peterson de Andrade, Soo-Tng Quah, Maxim Rossmann, Luca Laraia, Niklas Skold, Tze Jing Sum, Pamela J.E. Rowling, Thomas L. Joseph, Chandra Verma, Marko Hyvonen, Laura S. Itzhaki, Ashok R. Venkitaraman, Christopher J. Brown, David P. Lane, David R. Spring
29 Jan 2014 BMRC p53 Laboratory The Fluorescent Two-Hybrid Assay to Screen for Protein–Protein Interaction Inhibitors in Live Cells: Targeting the Interaction of p53 with Mdm2 and Mdm4 Larisa Yurlova, Maarten Derks, Andrea Buchfellner, Ian Hickson, Marc Janssen, Denise Morrison, Ian Stansfield, Christopher J. Brown, Farid J. Ghadessy, David P. Lane, Ulrich Rothbauer, Kourosh Zolghadr, Eberhard Krausz