Subramanian, G., Lam, W. J., Tham, E. H., Chandran, N. S., & Sampath, P. (2026). Decoding atopic dermatitis: pathophysiology, clinical diagnosis, and treatments. Trends in Molecular Medicine, 32(4), 416–417. https://doi.org/10.1016/j.molmed.2026.01.005
Abstract:
Atopic dermatitis (AD) is a common, chronic inflammatory skin disease with no validated biomarkers for predicting progression and no cure to date. Contributing factors include environmental triggers, allergens, and acute stress. The pathogenesis of AD involves immune dysregulation, environmental factors, and impaired skin barrier function. Skin microbiota has emerged as a significant therapeutic target in AD. New treatment modalities involving topical probiotics, phage therapy, and microbiome transplantations provide new avenues towards AD care.
License type:
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Funding Info:
This research / project is supported by the National Medical Research Council - Open Fund Young Individual Research Grant
Grant Reference no. : MOH-001351
This research / project is supported by the National Medical Research Council - Clinician Scientist Award
Grant Reference no. : MOH-001415