Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy

Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy

Nutrition, Metabolism and Cardiovascular Diseases

10.1016/j.numecd.2022.07.019

https://doi.org/10.1016/j.numecd.2022.07.019

Jun S. Lai, Wen Lun Yuan, Choon Nam Ong, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Peter D. Gluckman, Keith M. Godfrey, Yung Seng Lee, Jerry K.Y. Chan, Shiao-Yng Chan, Mary F.F. Chong

05 August 2022

Lai, J. S., Yuan, W. L., Ong, C. N., Tan, K. H., Yap, F., Chong, Y. S., Gluckman, P. D., Godfrey, K. M., Lee, Y. S., Chan, J. K. Y., Chan, S.-Y., & Chong, M. F. F. (2022). Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy. Nutrition, Metabolism and Cardiovascular Diseases, 32(12), 2811–2821. https://doi.org/10.1016/j.numecd.2022.07.019

Background and aims: Few studies examined the influence of carotenoids and vitamin E on blood pressure or hypertension during and after pregnancy. We related perinatal plasma concentrations of carotenoids and vitamin E (in individual forms and in combination) to blood pressure and hypertension at late pregnancy and 4 years post-pregnancy. Methods and results: In 684 women of the Growing Up in Singapore Towards Healthy Outcomes cohort, we quantified plasma carotenoids and vitamin E concentrations at delivery. Systolic blood pressure and diastolic blood pressure (SBP and DBP) around 37-39 weeks' gestation were extracted from obstetric records and measured at 4 years post-pregnancy. Principal component analysis derived patterns of carotenoids (CP) and vitamin E. Associations were examined using linear or logistic regressions adjusting for confounders. Two carotenoids (CP1: α-carotene, β-carotene, and lutein; CP2: zeaxanthin, lycopene, and β-cryptoxanthin) and one vitamin E (γ-, δ-, and α-tocopherols) patterns were derived. CP1 (1SD score increment) was associated with lower SBP and DBP [β (95% CI): -2.36 (-3.47, -1.26) and -1.37 (-2.21, -0.53) mmHg] at late pregnancy> and 4 years post-pregnancy [-1.45 (-2.72, -0.18) and -0.99 (-1.98, -0.01) mmHg]. Higher β-cryptoxanthin concentrations were associated with lower SBP and DBP [-1.50 (-2.49, -0.51) and -1.20 (-1.95, -0.46) mmHg] at late pregnancy. Individual vitamin E and their pattern were not associated with blood pressure or hypertension. Conclusion: Higher perinatal α-carotene, β-carotene, and lutein concentrations are associated with lower blood pressure in women at late pregnancy and post-pregnancy. Foods rich in these carotenoids, such as red-, orange-, and dark-green-colored vegetables, might be beneficial for blood pressure during and after pregnancy.

Publisher Copyright

This research / project is supported by the National Medical Research Council - Translational and Clinical Research (TCR) Programme
Grant Reference no. : NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014

Additional funding is provided by the Singapore Institute for Clinical Sciences, A*STAR, Ministry of Education’s Academic Research Fund Tier 1, and the 2018 BASF Nutrition Asia Research Grant.

https://oar.a-star.edu.sg/communities-collections/articles/22273

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