Sui, X., & Oehlers, S. H. (2025). Animal models of Mycobacterium abscessus pulmonary infection phenotypes: What are we modeling? PLOS Pathogens, 21(8), e1013414. https://doi.org/10.1371/journal.ppat.1013414
Abstract:
Pulmonary infections caused by Mycobacterium abscessus have been difficult to model as most wild-type mice rapidly clear infection across a range of inoculation routes. Existing animal models of M. abscessus infection can be broadly classified into acute overwhelming infection, self-limiting mucosal clearance, and chronic granulomatous pathologies. We will make the argument that each of these models potentially models distinct endotypes of M. abscessus infection and highlight opportunities to understand infection biology through comparison of experimental models.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the Singapore Ministry of Health National Medical Research Council - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG22jul-0081