Subramanian, G., Kalidasan, K., Quah, S., Han, Q. C., Gavin, Chan, J., Wacker, M. G., & Sampath, P. (2024). Breaking barriers: Innovative approaches for skin delivery of RNA therapeutics. International Journal of Pharmaceutics, 661, 124435. https://doi.org/10.1016/j.ijpharm.2024.124435
Abstract:
RNA therapeutics represent a rapidly expanding platform with game-changing prospects in personalized medicine. The disruptive potential of this technology will overhaul the standard of care with reference to both primary and specialty care. To date, RNA therapeutics have mostly been delivered parenterally via injection, but topical administration followed by intradermal or transdermal delivery represents an attractive method that is convenient to patients and minimally invasive. The skin barrier, particularly the lipid-rich stratum corneum, presents a significant hurdle to the uptake of large, charged oligonucleotide drugs. Therapeutic oligonucleotides need to be engineered for stability and specificity and formulated with state-of-the-art delivery strategies for efficient uptake. This review will cover various passive and active strategies deployed to enhance permeation through the stratum corneum and achieve effective delivery of RNA therapeutics to treat both local skin disorders and systemic diseases. Some strategies to achieve selectivity between local and systemic administration will also be discussed.
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Funding Info:
This research / project is supported by the NATIONAL MEDICAL RESEARCH COUNCIL - Individual Research Grant (IRG)
Grant Reference no. : MOH-000615
This research / project is supported by the Biomedical Research Council (BMRC) - Central Research Fund (CRF)
Grant Reference no. : NA
This research / project is supported by the Ministry of Education - Startup grant, Academic Research Fund Tier 1
Grant Reference no. : A-0004627-00-00, A-8001991-00-00