Multifunctional Silver‐Enzyme Nanogels Assembly with Efficient Trienzyme Cascades for Synergistic Diabetic Wound Healing

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Multifunctional Silver‐Enzyme Nanogels Assembly with Efficient Trienzyme Cascades for Synergistic Diabetic Wound Healing
Title:
Multifunctional Silver‐Enzyme Nanogels Assembly with Efficient Trienzyme Cascades for Synergistic Diabetic Wound Healing
Journal Title:
Advanced Functional Materials
Keywords:
Publication Date:
10 September 2024
Citation:
Ma, Y., Lai, X., Luo, X., Luo, Z., Mao, L., Zhu, H., Fan, X., Kong, J., Wu, Y., Li, Z., & He, C. (2024). Multifunctional Silver‐Enzyme Nanogels Assembly with Efficient Trienzyme Cascades for Synergistic Diabetic Wound Healing. Advanced Functional Materials, 34(45). Portico. https://doi.org/10.1002/adfm.202405644
Abstract:
Diabetic wound healing presents a persistent clinical challenge, often characterized by prolonged healing times, and can be particularly difficult to achieve in a hyperglycemic environment. In this study, a multi‐functional silver‐enzyme nanogels assembly (Ag‐nGHC) is designed by focusing on the complex diabetic wound environment. Glucose oxidase (GOX), horseradish peroxidase (HRP), and catalase (CAT) are modified within polymeric nanogel layers and assembled into a large enzyme cluster with silver ions. The close attachment of three enzymes ensures fast and continuous consumption of a high level of glucose, generation of oxygen, and hydroxyl radicals (•OH) around the wound site. Meanwhile, the silver ions within the Ag‐nGHC assembly act as an effective agent to kill bacteria. This cascade enzyme system significantly improves the microenvironment of the wound site by reducing bacterium infection and alleviating hypoxia as well as hyperglycemia. Sequentially, the improved environment facilitates the later processes including anti‐inflammatory, re‐epithelialization, and angiogenesis, evidenced by enhancing polarization toward M2 macrophages and increasing CD31 signals in this study. Overall, the Ag‐nGHC materials are proven to achieve multifunctional properties toward complicated diabetic wound healing processes (attributes such as adaptability, hypoxia‐alleviated, anti‐hyperglycemic, antimicrobial, anti‐inflammatory, and angiogenic) and showed great potential for the treatment of chronic diabetic wound.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the Ministry of Education - Academic Research Fund Tier 2
Grant Reference no. : T25-2401-P01

This research is supported by core funding from: Science and Engineering Research Council (SERC) Central Research Fund (Use-Inspired Basic Research)
Grant Reference no. : NA
Description:
This is the peer reviewed version of the following article: Ma, Y., Lai, X., Luo, X., Luo, Z., Mao, L., Zhu, H., Fan, X., Kong, J., Wu, Y., Li, Z., & He, C. (2024). Multifunctional Silver‐Enzyme Nanogels Assembly with Efficient Trienzyme Cascades for Synergistic Diabetic Wound Healing. Advanced Functional Materials, 34(45). Portico. https://doi.org/10.1002/adfm.202405644, which has been published in final form at https://doi.org/10.1002/adfm.202405644. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
ISSN:
1616-301X
1616-3028
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