Tong Jia Ming, S., Tan Yi Jun, K., & Carissimo, G. (2024). Pathogenicity and virulence of O’nyong-nyong virus: A less studied Togaviridae with pandemic potential. Virulence, 15(1). https://doi.org/10.1080/21505594.2024.2355201
Abstract:
O’nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the Togaviridae family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa. As climate change increases the geographical range of known and potential new vectors, recent data indicates a possibility for ONNV to spread outside of the African continent and grow into a greater public health concern. In this review, we summarise the current knowledge on ONNV epidemiology, host–pathogen interactions, vector-virus responses, and insights into possible avenues to control the risk of further epidemics. In this review, the limited ONNV literature is compared and correlated to other findings on mainly Old World alphaviruses. We highlight and discuss studies that investigate viral and host factors that determine viral-vector specificity, along with important mechanisms that determine severity and disease outcome of ONNV infection.
License type:
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Funding Info:
This research is supported by core funding from: A*STAR Infectious Diseases Labs
Grant Reference no. :
This research / project is supported by the Biomedical Research Council (BMRC) of Agency for Science, Technology and Research (A*STAR), National Medical Research Council (NMRC) - Open Fund Young Investigator Research
Grant Reference no. : OFYIRG19nov-0051
Description:
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.