Stretchable ionic–electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers

Page view(s)
15
Checked on Feb 12, 2025
Stretchable ionic–electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers
Title:
Stretchable ionic–electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers
Journal Title:
Nature Materials
Publication Date:
12 June 2024
Citation:
Arwani, R. T., Tan, S. C. L., Sundarapandi, A., Goh, W. P., Liu, Y., Leong, F. Y., Yang, W., Zheng, X. T., Yu, Y., Jiang, C., Ang, Y. C., Kong, L., Teo, S. L., Chen, P., Su, X., Li, H., Liu, Z., Chen, X., Yang, L., & Liu, Y. (2024). Stretchable ionic–electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers. Nature Materials, 23(8), 1115–1122. https://doi.org/10.1038/s41563-024-01918-9
Abstract:
Continuous and in situ detection of biomarkers in biofluids (for example, sweat) can provide critical health data but is limited by biofluid accessibility. Here we report a sensor design that enables in situ detection of solid-state biomarkers ubiquitously present on human skin. We deploy an ionic– electronic bilayer hydrogel to facilitate the sequential dissolution, diffusion and electrochemical reaction of solid-state analytes. We demonstrate continuous monitoring of water-soluble analytes (for example, solid lactate) and water-insoluble analytes (for example, solid cholesterol) with ultralow detection limits of 0.51 and 0.26 nmol cm−2, respectively. Additionally, the bilayer hydrogel electrochemical interface reduces motion artefacts by a factor of three compared with conventional liquid-sensing electrochemical interfaces. In a clinical study, solid-state epidermal biomarkers measured by our stretchable wearable sensors showed a high correlation with biomarkers in human blood and dynamically correlated with physiological activities. These results present routes to universal platforms for biomarker monitoring without the need for biofluid acquisition.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the A*STAR - AME Programmatic Cyber-Physiochemical Interfaces
Grant Reference no. : A18A1b0045

This research / project is supported by the A*STAR - MTC Programmatic ‘BLISS’
Grant Reference no. : M24M9b0013

This research / project is supported by the Singapore National Research Foundation - Singapore National Research Foundation Fellowship
Grant Reference no. : NRF-NRFF15-2023-0011

This research is supported by core funding from: A*STAR Central Research Fund
Grant Reference no. : NA

This research / project is supported by the National University of Singapore - National University of Singapore Presidential Young Professorship Award
Grant Reference no. : 22-4974-A0003

This research / project is supported by the National University of Singapore - Advanced Research and Technology Innovation Centre
Grant Reference no. : HFM-RP6

This research / project is supported by the Ministry of Education, Singapore and Temasek Trust - Wellcome Leap’s Dynamic Resilience Program
Grant Reference no. : 22-5402-A0001-0

This project is funded by iHealthtech under iHealthtech Other Operating Expenses (OOE) funding
Description:
For the publisher's version, refer here: https://www.nature.com/articles/s41563-024-01918-9
ISSN:
1476-1122
1476-4660
Files uploaded:






File Size Format Action
corrections-copy.docx 351.86 KB DOCX Open
supplementary-information.pdf 9.94 MB PDF Open
fig-4.png 401.06 KB PNG Open
fig-1.png 911.32 KB PNG Open
fig-2.png 216.39 KB PNG Open
fig-3.png 749.73 KB PNG Open