Akbarzadeh, F. Z., Sarraf, M., Ghomi, E. R., Kumar, V. V., Salehi, M., Ramakrishna, S., & Bae, S. (2024). A state-of-the-art review on recent advances in the fabrication and characteristics of magnesium-based alloys in biomedical applications. Journal of Magnesium and Alloys. https://doi.org/10.1016/j.jma.2024.06.015
Abstract:
Magnesium (Mg) and its alloys have recently gained increasing attention in the biomedical field as promising biodegradable materials with harmless degradation products. Magnesium-based alloys have a wide range of biomedical applications because of their outstanding biocompatibility and unique mechanical properties. Widespread use of Mg-based biomedical devices eliminates the need for post-healing biomaterial removal surgery and minimizes the negative consequences of the implantation of permanent biomaterials, including stress shielding and undesired metal ion release in the body. This paper provides a literature review on the properties and manufacturing methods of Mg-based alloys for biomedical applications, including orthopedic implants, cardiovascular applications, surgical wires and staplers, and antitumor activities. Each application of Mg-based biomaterials is investigated from a biological perspective, including matching functional properties, biocompatibility, host tissue responses, and anti-microbial strategies, along with potential additive manufacturing technologies for these applications. Finally, an outlook is presented to provide recommendations for Mg-based biomaterials in the future.
License type:
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
This research / project is supported by the The Korean Government (MSIT) - National Research Foundation of Korea (NRF) grant
Grant Reference no. : RS-2023-00207763, NRF-2022R1A2C2010350