A Western Diet Alters Skin Ceramides and Compromises the Skin Barrier in Ears

A Western Diet Alters Skin Ceramides and Compromises the Skin Barrier in Ears

Journal of Investigative Dermatology

10.1016/j.jid.2021.12.017

http://dx.doi.org/10.1016/j.jid.2021.12.017

Kahbing Jasmine Tan, Satoshi Nakamizo, Hyeon-Cheol Lee-Okada, Reiko Sato, Zachary Chow, Saeko Nakajima, John E.A. Common, Kazuko Saeki, Takehiko Yokomizo, Florent Ginhoux, Kenji Kabashima

Genetics and Molecular Biology

07 January 2022

Tan, K. J., Nakamizo, S., Lee-Okada, H.-C., Sato, R., Chow, Z., Nakajima, S., Common, J. E. A., Saeki, K., Yokomizo, T., Ginhoux, F., & Kabashima, K. (2022). A Western Diet Alters Skin Ceramides and Compromises the Skin Barrier in Ears. Journal of Investigative Dermatology, 142(7), 2020-2023.e2. https://doi.org/10.1016/j.jid.2021.12.017

The skin is an organ that acts as an essential barrier between the outside world and the inside of the body. When this natural defense function is compromised, it can lead to xerosis, inflammation, chronic dermatitis, and other skin conditions (Kubo et al.,2012). Several studies have reported that diet can affect skin barrier function (Parke et al., 2021). For example, docosahexaenoic acid, a type of omega-3 fatty acid, is known to increase the expression of FLG, a component of the skin’s natural moisturizing factor (Wallmeyer et al., 2015). Interestingly, body mass index has been reported to be associated with disease onset in atopic dermatitis (AD), where barrier impairment is implicated (Ascott et al.,2021). It is widely accepted that weight gain is related to the westernization of food (Astrup et al., 2008). Therefore, we investigated the relationship between the western diet (WD) and the skin barrier using a mouse model.

Attribution 4.0 International (CC BY 4.0)

This research / project is supported by the European Molecular Biology Organization - Young Investigator Programme
Grant Reference no. : NA

This research is supported by core funding from: Singapore Immunology Network (SIgN), Skin Research Institute of Singapore core funding (A*STAR)
Grant Reference no. : NA

This research / project is supported by the Agency for Science, Technology and Research, National Health Group, National Technological University - Skin research grant
Grant Reference no. : 15014

This research / project is supported by the Japan Society for the Promotion of Science - KAKENHI
Grant Reference no. : 20H05697

This research / project is supported by the Japan Agency for Medical Research and Development - NA
Grant Reference no. : JP21gm1210006

This research / project is supported by the Japanese Dermatological Association - Basic Medical Research Grant
Grant Reference no. : NA

This research / project is supported by the Japan Society for the Promotion of Science - KAKENHI
Grant Reference no. : 21K16211

https://oar.a-star.edu.sg/communities-collections/articles/20089

0022-202X

Skin Research Lab