Editorial: Novel aspects of the immunological and structural barrier of the epidermis

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Editorial: Novel aspects of the immunological and structural barrier of the epidermis
Title:
Editorial: Novel aspects of the immunological and structural barrier of the epidermis
Journal Title:
Frontiers in Molecular Biosciences
Keywords:
Publication Date:
01 November 2023
Citation:
O’Shaughnessy, R., Common, J., & Gutowska-Owsiak, D. (2023). Editorial: Novel aspects of the immunological and structural barrier of the epidermis. Frontiers in Molecular Biosciences, 10. https://doi.org/10.3389/fmolb.2023.1324920
Abstract:
The importance of the epidermal barrier as a multifaceted mechanistic unit supporting whole-body homeostasis continues to grow in prominence. The spotlight again points towards this vital barrier tissue with the recent realization of significant importance for novel aspects in preventing skin diseases and skin infections, that have been tightly associated with atopic dermatitis (AD) and psoriasis. Unchecked, percutaneous defects progress to atopic diathesis and linked systemic manifestations. To this end, the skin provides interlinked mechanical, immunological, and antimicrobial protection, formed through keratinocyte differentiation, generating a multi-layered tissue with a structural and protective function. In addition, multiple cell types including keratinocytes, melanocytes, and immune cells crosstalk within the skin to create the first line of protection against pathogens and environmental threats, through the production of immunological mediators, recruitment of humoral and cellular immunity as well as the hosting of a commensal microbiome. The goal of this Research Topic was to bring together the latest advances and insights of epidermal biology, emphasizing both its immunological and physical aspects, providing a platform to present novel findings and summarise current knowledge, from both basic science and the clinical perspective. To this end, ten publications were accepted covering a broad range of research areas for epidermal barrier function in the form of 4 original articles and 6 reviews.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
There was no specific funding for the research done
Description:
ISSN:
2296-889X
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