O’Shaughnessy, R., Common, J., & Gutowska-Owsiak, D. (2023). Editorial: Novel aspects of the immunological and structural barrier of the epidermis. Frontiers in Molecular Biosciences, 10. https://doi.org/10.3389/fmolb.2023.1324920
Abstract:
The importance of the epidermal barrier as a multifaceted mechanistic unit supporting
whole-body homeostasis continues to grow in prominence. The spotlight again points
towards this vital barrier tissue with the recent realization of significant importance for novel
aspects in preventing skin diseases and skin infections, that have been tightly associated with
atopic dermatitis (AD) and psoriasis. Unchecked, percutaneous defects progress to atopic
diathesis and linked systemic manifestations. To this end, the skin provides interlinked
mechanical, immunological, and antimicrobial protection, formed through keratinocyte
differentiation, generating a multi-layered tissue with a structural and protective function. In
addition, multiple cell types including keratinocytes, melanocytes, and immune cells
crosstalk within the skin to create the first line of protection against pathogens and
environmental threats, through the production of immunological mediators, recruitment
of humoral and cellular immunity as well as the hosting of a commensal microbiome. The
goal of this Research Topic was to bring together the latest advances and insights of
epidermal biology, emphasizing both its immunological and physical aspects, providing a
platform to present novel findings and summarise current knowledge, from both basic
science and the clinical perspective. To this end, ten publications were accepted covering a
broad range of research areas for epidermal barrier function in the form of 4 original articles
and 6 reviews.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
There was no specific funding for the research done