Moeglen Paget, B., Vinod Ram, K., Zhang, S., Perumal, J., Vedraine, S., Humbert, G., Olivo, M., & Dinish, U. S. (2024). A review on photonic crystal fiber based fluorescence sensing for chemical and biomedical applications. Sensors and Actuators B: Chemical, 400, 134828. https://doi.org/10.1016/j.snb.2023.134828
Abstract:
Photonic crystal fibers (PCFs) have received tremendous interest in recent years for many biomedical applications
due to their unique light-guiding properties. PCF based fluorescence sensors are providing a new paradigm
in highly sensitive detection of biomolecules at very low sample volumes. Specific PCFs, including hollow-core
PCFs and solid-core PCFs, are highly efficient optofluidic sensing platforms as they address the key challenges by
providing a long interaction length between guided light and biological analyte residing in the micro-capillary
holes that run along the entire length of the fiber. This review includes an overview of the recent advancements
in fluorescence detection with various PCF configurations and provides a comparison between existing
conventional fluorescence methods for chemical and clinical applications. A critical insight into novel PCF based
fluorescence sensing configurations, and their prospective/potential applications will be discussed. Future perspectives on translating such probes as an optofluidic biopsy needle for clinically relevant biomarker detection
will also be included.
License type:
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
This work is supported by institutional grants from the National
Research Agency under the Investments for the future program with the reference ANR-18-EURE-0017 TACTIC, the CASI from XLIM ResearchInstitute and the A*STAR graduate academy. Authors also acknowledge the funding support from ANR-NRF grant, NRF2021-NRF-ANR002 FUNSENS and A*STAR CRF (UIBR) grant. This work was conducted within the frame of the International Research Project “FiberMed” between CNRS, A*STAR and Univ. Limoges. BMP also acknowledge the funding support from A*STAR Research and Attachment Program (ARAP), A*STAR Singapore.