Household environmental microbiota influences early‐life eczema development

Household environmental microbiota influences early‐life eczema development

Environmental Microbiology

10.1111/1462-2920.15684

http://dx.doi.org/10.1111/1462-2920.15684

Le Duc Huy Ta, Carina Jing Xuan Tay, Christophe Lay, Paola Florez De Sessions, Cheryl Pei Ting Tan, Michelle Jia Yu Tay, Hui Xing Lau, Atiqa Binte Zulkifli, Gaik Chin Yap, Elizabeth Huiwen Tham, Eliza Xin Pei Ho, Anne Eng Neo Goh, Keith M Godfrey, Johan G Eriksson, Jan Knol, Peter D Gluckman, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Kok Wee Chong, Si Hui Goh, Zai Ru Cheng, Bee Wah Lee, Lynette Pei‐chi Shek, Evelyn Xiu Ling Loo

early-life exposure, Eczema, household environmental bacteria, Planomicrobium, preconception

26 July 2021

Ta, L. D. H., Tay, C. J. X., Lay, C., de Sessions, P. F., Tan, C. P. T., Tay, M. J. Y., Lau, H. X., Zulkifli, A. B., Yap, G. C., Tham, E. H., Ho, E. X. P., Goh, A. E. N., Godfrey, K. M., Eriksson, J. G., Knol, J., Gluckman, P. D., Chong, Y. S., Chan, J. K. Y., Tan, K. H., … Loo, E. X. L. (2021). Household environmental microbiota influences early‐life eczema development. Environmental Microbiology, 23(12), 7710–7722. Portico. https://doi.org/10.1111/1462-2920.15684

Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S‐PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human‐associated bacteria Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium (Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human‐associated bacteria (Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium). Exposure to natural environmental microbiota may be beneficial to modulate shed human‐associated microbiota in an indoor environment.

Publisher Copyright

This research / project is supported by the National Medical Research Council - Open Fund Young Investigator Grant
Grant Reference no. : NMRC/OFYIRG/015/2016-00

This research / project is supported by the National Medical Research Council - Translational and Clinical Research (TCR) Flagship Program
Grant Reference no. : NMRC/TCR/004-NUS/2008

This research / project is supported by the National Medical Research Council - Translational and Clinical Research (TCR) Flagship Program
Grant Reference no. : NMRC/TCR/012-NUHS/2014

This research is supported by core funding from: Singapore Institute for Clinical Sciences
Grant Reference no. : NA

This is the peer reviewed version of the following article: Ta, L. D. H., Tay, C. J. X., Lay, C., de Sessions, P. F., Tan, C. P. T., Tay, M. J. Y., Lau, H. X., Zulkifli, A. B., Yap, G. C., Tham, E. H., Ho, E. X. P., Goh, A. E. N., Godfrey, K. M., Eriksson, J. G., Knol, J., Gluckman, P. D., Chong, Y. S., Chan, J. K. Y., Tan, K. H., … Loo, E. X. L. (2021). Household environmental microbiota influences early‐life eczema development. Environmental Microbiology, 23(12), 7710–7722. Portico., which has been published in final form at https://doi.org/10.1111/1462-2920.15684. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

https://oar.a-star.edu.sg/communities-collections/articles/19936

1462-2912
1462-2920

Singapore Institute for Clinical Sciences