Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort

Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort

BMC Pregnancy and Childbirth

10.1186/s12884-021-04036-5

http://dx.doi.org/10.1186/s12884-021-04036-5

Evelyn Xiu Ling Loo, Yuqing Zhang, Qai Ven Yap, Guoqi Yu, Shu E Soh, See Ling Loy, Hui Xing Lau, Shiao-Yng Chan, Lynette Pei-chi Shek, Zhong-Cheng Luo, Fabian Kok Peng Yap, Kok Hian Tan, Yap Seng Chong, Jun Zhang, Johan Gunnar Eriksson

18 August 2021

Loo, E. X. L., Zhang, Y., Yap, Q. V., Yu, G., Soh, S. E., Loy, S. L., Lau, H. X., Chan, S.-Y., Shek, L. P.-C., Luo, Z.-C., Yap, F. K. P., Tan, K. H., Chong, Y. S., Zhang, J., & Eriksson, J. G. (2021). Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort. BMC Pregnancy and Childbirth, 21(1). https://doi.org/10.1186/s12884-021-04036-5

Abstract Background Gestational diabetes mellitus (GDM) has been associated with adverse health outcomes for mothers and offspring. Prevalence of GDM differs by country/region due to ethnicity, lifestyle and diagnostic criteria. We compared GDM rates and risk factors in two Asian cohorts using the 1999 WHO and the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Methods The Shanghai Birth Cohort (SBC) and the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort are prospective birth cohorts. Information on sociodemographic characteristics and medical history were collected from interviewer-administered questionnaires. Participants underwent a 2-h 75-g oral glucose tolerance test at 24–28 weeks gestation. Logistic regressions were performed. Results Using the 1999 WHO criteria, the prevalence of GDM was higher in GUSTO (20.8%) compared to SBC (16.6%) (p = 0.046). Family history of hypertension and alcohol consumption were associated with higher odds of GDM in SBC than in GUSTO cohort while obesity was associated with higher odds of GDM in GUSTO. Using the IADPSG criteria, the prevalence of GDM was 14.3% in SBC versus 12.0% in GUSTO. A history of GDM was associated with higher odds of GDM in GUSTO than in SBC, while being overweight, alcohol consumption and family history of diabetes were associated with higher odds of GDM in SBC. Conclusions We observed several differential risk factors of GDM among ethnic Chinese women living in Shanghai and Singapore. These findings might be due to heterogeneity of GDM reflected in diagnostic criteria as well as in unmeasured genetic, lifestyle and environmental factors.

Attribution 4.0 International (CC BY 4.0)

This research / project is supported by the National Medical Research Council - Translational and Clinical Research (TCR) Flagship Program
Grant Reference no. : NMRC/TCR/004-NUS/2008

This research / project is supported by the National Medical Research Council - Translational and Clinical Research (TCR) Flagship Program
Grant Reference no. : NMRC/TCR/012-NUHS/2014

This research is supported by core funding from: Singapore Institute for Clinical Sciences
Grant Reference no. : NA

Supported by the Shanghai Municipal Health Commission (GWIII-26.1, GWIV-26.1, 2020CXJQ01).

https://oar.a-star.edu.sg/communities-collections/articles/19934

1471-2393

Singapore Institute for Clinical Sciences

https://doi.org/10.1186/s12884-021-04036-5