A portable optical pulsatile flowmetry demonstrates strong clinical relevance for diabetic foot perfusion assessment

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A portable optical pulsatile flowmetry demonstrates strong clinical relevance for diabetic foot perfusion assessment
Title:
A portable optical pulsatile flowmetry demonstrates strong clinical relevance for diabetic foot perfusion assessment
Journal Title:
APL Bioengineering
Keywords:
Publication Date:
21 February 2024
Citation:
Bi, R., Zhang, R., Meng, L., Du, Y., Low, J., Qi, Y., Rajarahm, P., Lai, A. Y. F., Tan, V. S. Y., Ho, P., & Olivo, M. (2024). A portable optical pulsatile flowmetry demonstrates strong clinical relevance for diabetic foot perfusion assessment. APL Bioengineering, 8(1). https://doi.org/10.1063/5.0182670
Abstract:
We present a robust, cost-effective (<2000 USD), and portable optical diffuse speckle pulsatile flowmetry (DSPF) device with a flexible handheld probe for deep tissue blood flow measurement in the human foot as well as a first-in-man observational clinical study using the proposed optical device for tissue ischemia assessment and peripheral artery disease (PAD) diagnosis. Blood flow in tissue is inherently pulsatile in nature. However, most conventional methods cannot measure deep tissue-level pulsatile blood flow noninvasively. The proposed optical device can measure tissue-level pulsatile blood flow ∼6 mm underneath the skin surface. A new quantitative tissue perfusion index (TPIDSPF) based on frequency domain analysis of the pulsatile blood flow waveform is defined to assess tissue ischemia status. Through a clinical study involving 66 subjects, including healthy individuals and diabetes patients with and without PAD, TPIDSPF demonstrated strong correlations of 0.720 with transcutaneous tissue partial oxygen pressure (TcPO2) and 0.652 with toe–brachial index (TBI). Moreover, among the three methods, TPIDSPF demonstrated the highest area under the curve for PAD diagnosis among diabetes patients, with a notable value of 0.941. The promising clinical results suggest that the proposed optical method has the potential to be an effective clinical tool for identifying PAD among the diabetic cohort.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the ASTAR, Biomedical Research Council (BMRC) - Central Research Fund - (ATR) 2021
Grant Reference no. : NA

This research / project is supported by the ASTAR, Biomedical Research Council (BMRC) - Central Research Fund - UIBR
Grant Reference no. : NA

This research / project is supported by the ASTAR - Industry Alignment Fund prepositioning program
Grant Reference no. : H19/01/a0/0EE9

This research / project is supported by the Biomedical Engineering Programme - Biomedical Engineering Programme
Grant Reference no. : C221318003

This research / project is supported by the ASTAR - Gap Project
Grant Reference no. : I22AEAG006
Description:
ISSN:
2473-2877
Collections: