A Patent Review on SARS Coronavirus Papain‐Like Protease (PL<sup>pro</sup>) Inhibitors

Page view(s)
62
Checked on Feb 09, 2025
A Patent Review on SARS Coronavirus Papain‐Like Protease (PL<sup>pro</sup>) Inhibitors
Title:
A Patent Review on SARS Coronavirus Papain‐Like Protease (PL<sup>pro</sup>) Inhibitors
Journal Title:
ChemMedChem
Publication Date:
30 May 2023
Citation:
Brian Chia, C. S., & Pheng Lim, S. (2023). A Patent Review on SARS Coronavirus Papain‐Like Protease (PLpro) Inhibitors. ChemMedChem, 18(16). Portico. https://doi.org/10.1002/cmdc.202300216
Abstract:
AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is an unprecedented global health emergency causing more than 6.6 million fatalities by 31 December 2022. So far, only three antiviral drugs have been granted emergency use authorisation or approved by the FDA. The SARS‐CoV‐2 papain‐like protease (PLpro) is deemed an attractive drug target as it plays an essential role in viral polyprotein processing and pathogenesis although no inhibitors have yet been approved. This patent review discusses coronavirus PLpro inhibitors reported in patents published between 1 January 2003 to 2 March 2023, giving an overview on the inhibitors that have generated commercial interest, especially amongst drug companies.
License type:
Publisher Copyright
Funding Info:
This research is supported by core funding from: Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10 Biopolis Road, Chromos #08-01, Singapore, 138670 Singapore
Grant Reference no. : N. A.
Description:
This is the peer reviewed version of the following article: Brian Chia, C. S., & Pheng Lim, S. (2023). A Patent Review on SARS Coronavirus Papain‐Like Protease (PLpro) Inhibitors. ChemMedChem, 18(16). Portico. https://doi.org/10.1002/cmdc.202300216, which has been published in final form at doi.org/10.1002/cmdc.202300216. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
ISSN:
1860-7179
1860-7187
Files uploaded: