Nagarajan, A., Robinson, N., Ang, K. K., Chua, K. S. G., Chew, E., & Guan, C. (2024). Transferring a deep learning model from healthy subjects to stroke patients in a motor imagery brain–computer interface. Journal of Neural Engineering, 21(1), 016007. https://doi.org/10.1088/1741-2552/ad152f
Abstract:
Abstract
Objective. Motor imagery (MI) brain–computer interfaces (BCIs) based on electroencephalogram (EEG) have been developed primarily for stroke rehabilitation, however, due to limited stroke data, current deep learning methods for cross-subject classification rely on healthy data. This study aims to assess the feasibility of applying MI-BCI models pre-trained using data from healthy individuals to detect MI in stroke patients. Approach. We introduce a new transfer learning approach where features from two-class MI data of healthy individuals are used to detect MI in stroke patients. We compare the results of the proposed method with those obtained from analyses within stroke data. Experiments were conducted using Deep ConvNet and state-of-the-art subject-specific machine learning MI classifiers, evaluated on OpenBMI two-class MI-EEG data from healthy subjects and two-class MI versus rest data from stroke patients. Main results. Results of our study indicate that through domain adaptation of a model pre-trained using healthy subjects’ data, an average MI detection accuracy of 71.15% (
±
12.46
%
) can be achieved across 71 stroke patients. We demonstrate that the accuracy of the pre-trained model increased by 18.15% after transfer learning (p
<
0.001). Additionally, the proposed transfer learning method outperforms the subject-specific results achieved by Deep ConvNet and FBCSP, with significant enhancements of 7.64% (p
<
0.001) and 5.55% (p
<
0.001) in performance, respectively. Notably, the healthy-to-stroke transfer learning approach achieved similar performance to stroke-to-stroke transfer learning, with no significant difference (p
>
0.05). Explainable AI analyses using transfer models determined channel relevance patterns that indicate contributions from the bilateral motor, frontal, and parietal regions of the cortex towards MI detection in stroke patients. Significance. Transfer learning from healthy to stroke can enhance the clinical use of BCI algorithms by overcoming the challenge of insufficient clinical data for optimal training.
License type:
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
This research / project is supported by the A*STAR - RIE2020 AME Programmatic Fund
Grant Reference no. : A20G8b0102
Description:
This is the Accepted Manuscript version of an article accepted for publication in Journal of Neural Engineering. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at doi.org/10.1088/1741-2552/ad152f