Harnessing novel strategies and cell types to overcome immune tolerance during adoptive cell therapy in cancer

Page view(s)
369
Checked on Jul 19, 2024
Harnessing novel strategies and cell types to overcome immune tolerance during adoptive cell therapy in cancer
Title:
Harnessing novel strategies and cell types to overcome immune tolerance during adoptive cell therapy in cancer
Journal Title:
Journal for ImmunoTherapy of Cancer
Publication Date:
26 April 2023
Citation:
Neo, S. Y., Xu, S., Chong, J., Lam, K.-P., & Wu, J. (2023). Harnessing novel strategies and cell types to overcome immune tolerance during adoptive cell therapy in cancer. Journal for ImmunoTherapy of Cancer, 11(4), e006434. https://doi.org/10.1136/jitc-2022-006434
Abstract:
Cell therapy encompasses an expanding spectrum of cell-based regimes for the treatment of human ailments, such as the use of immune cells, in particular T cells, for combating tumors and the modulation of inflammatory immune responses. In this review, we focus on cell therapy in the immuno-oncology space, which is largely driven by interests and demands from the clinics for better solutions to target various hard-to-treat cancers. We discuss recent advances in various types of cell therapies, including T cell receptor-T cells, chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes and natural killer cells. Particularly, the present review focuses on the strategies to improve therapeutic responses by either enhancing tumor recognition or the resilience of infused immune cells within tumor microenvironment. Finally, we discuss the potential of other innate or innate-like immune cell types currently being explored as promising CAR-cell alternatives that seek to address the limitations of conventional adoptive cell therapies.
License type:
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Funding Info:
This research / project is supported by the National Research Foundation - Competitive Research Programme (CRP)
Grant Reference no. : NRF-CRP26-2021RS-0001

This research / project is supported by the National Medical Research Council - Open Fund - Large Collaborative Grant
Grant Reference no. : NMRC/OFLCG/003/2018

Taishan Scholar Program of Shandong Province (To Jing Wu), Shandong Natural Science Foundation (ZR2022MH001), National Natural Science Foundation of China (No. 81703617) and Shandong Provincial Qianfoshan Hospital Culture Foundation (No. QYPY-RC2022NSFC1003)
Description:
ISSN:
2051-1426