Lee, X. E., & Dreesen, O. (2023). Sun Exposure and its Impact on Keratinocyte Senescence and Function. Journal of Investigative Dermatology, 143(4), 529–530. https://doi.org/10.1016/j.jid.2022.12.010
Abstract:
Aging is characterized by a time-dependent decline of cellular and organismal function. The skin is the largest organ of the body and protects it against environmental insults such as ultraviolet (UV) radiation and pollution, various stresses including microbes and mechanical forces, and also plays a role in thermoregulation. In the skin, the aging process commonly manifests as observable phenotypes, such as wrinkling, thinning, loss of elasticity and aberrant pigmentation (Fitsiou et al. 2021; Wang and Dreesen 2018). Over the years, many studies have characterized the various features of aged skin. However, the exact molecular mechanisms and cellular processes that drive skin aging, and how the different skin cell types contribute to the various aging phenotypes remains elusive. Now, a new study by Bauwens et al. (2022) provides novel insight into the mechanism of skin aging and how this may lead to tissue dysfunction. In particular, the authors provide insight on how UVB exposure triggers premature senescence in skin keratinocytes and how this in turn modulates their function and environment.
License type:
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
This research is supported by core funding from: A*STAR Skin Research Labs ASRL
Grant Reference no. : N.A.