Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring

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Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring
Title:
Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring
Journal Title:
IEEE Transactions on Biomedical Engineering
Publication Date:
02 August 2023
Citation:
Zhang, R., Li, X., Balasundaram, G., Li, B., Qi, Y., Santosa, A., Tan, T. C., Olivo, M., & Bi, R. (2023). Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring. IEEE Transactions on Biomedical Engineering, 1–5. https://doi.org/10.1109/tbme.2023.3301013
Abstract:
Lewis hunting reaction refers to the alternating cold-induced vasoconstriction and dilation in extremities, whose underlying mechanism is complex. While numerous studies reported this intriguing phenomenon by measuring cutaneous temperature fluctuation under cold exposure, few of them tracked peripheral vascular responses in real-time, lacking a non-invasive and quantitative imaging tool. To better monitor hunting reaction and diagnose relevant diseases, we developed a hybrid photoacoustic ultrasound (PAUS) tomography system to monitor finger vessels’ dynamic response to cold, together with simultaneous temperature measurement. We also came out a standard workflow for image analysis with self-defined indices. In the small cohort observational study, vascular changes in the first cycle of hunting reaction were successfully captured by the image series and quantified. Time difference between vasodilation and temperature recovery was noticed and reported for the first time, thanks to the unique capability of the PAUS imaging system in real-time and continuous vascular monitoring. The developed imaging system and indices enabled more objective and quantitative monitoring of peripheral vascular activities, indicating its great potential in numerous clinical applications.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the A*STAR - BMRC Central Research Fund (UIBR) 2021
Grant Reference no. : NA

This research / project is supported by the A*STAR - BMRC Central Research Fund (ATR) 2021
Grant Reference no. : NA

This research / project is supported by the A*STAR - Horizontal Technology Programme Office Seed Fund, Biomedical Engineering Programme 2021
Grant Reference no. : C211318004

This research / project is supported by the A*STAR - Industry Alignment Fund prepositioning program
Grant Reference no. : H19H6a0025
Description:
© 2023 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
ISSN:
1558-2531
0018-9294
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