Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

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Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins
Title:
Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins
Journal Title:
Membranes
Publication Date:
18 February 2022
Citation:
Li, Q., & Kang, C. (2022). Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins. Membranes, 12(2), 231. https://doi.org/10.3390/membranes12020231
Abstract:
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins. Four of the seven nonstructural proteins, NS2A, NS2B, NS4A and NS4B, are membrane proteins. Unlike NS3 or NS5, these proteins do not harbor any enzymatic activities, but they play important roles in viral replication through interactions with viral or host proteins to regulate important pathways and enzymatic activities. The location of these proteins on the cell membrane and the functional roles in viral replication make them important targets for antiviral development. Indeed, NS4B inhibitors exhibit antiviral activities in different assays. Structural studies of these proteins are hindered due to challenges in crystallization and the dynamic nature of these proteins. In this review, the function and membrane topologies of dengue nonstructural membrane proteins are presented. The roles of solution NMR spectroscopy in elucidating the structure and dynamics of these proteins are introduced. The success in the development of NS4B inhibitors proves that this class of proteins is an attractive target for antiviral development.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research is supported by core funding from: Experimental Drug Development Centre
Grant Reference no. : NRF2021-IE-IECF-001
Description:
ISSN:
2077-0375
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