Yeo, S. J., Ying, C., Fullwood, M. J., & Tergaonkar, V. (2023). Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains. Trends in Genetics. https://doi.org/10.1016/j.tig.2022.12.003
Abstract:
Topologically associating domains (TADs) are integral to spatial genome organization, instructing gene expression, and cell fate. Recently, several advances have uncovered roles for noncoding RNAs (ncRNAs) in the regulation of the form and function of mammalian TADs. Phase separation has also emerged as a potential arbiter of ncRNAs in the regulation of TADs. In this review we discuss the implications of these novel findings in relation to how ncRNAs might structurally and functionally regulate TADs from two perspectives: moderating loop extrusion through interactions with architectural proteins, and facilitating TAD phase separation. Additionally, we propose future studies and directions to investigate these phenomena.
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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Funding Info:
This research is supported by core funding from: Agency for Science, Technology and Research (A*STAR)
Grant Reference no. : UIBR
This research / project is supported by the National Research Foundation - Competitive Research Program grant
Grant Reference no. : NRF-CRP26-2021-0001
This research / project is supported by the National Medical Research Council (NMRC) - Open Fund - Individual Research Grant
Grant Reference no. : OFIRG21jun-0101
This research / project is supported by the Ministry of Education (MOE) - Academic Research Fund Tier 1 grant
Grant Reference no. : RG86/21
This research / project is supported by the Ministry of Education (MOE) - Academic Research Fund Tier 2 grant
Grant Reference no. : MOE-T2EP30120-0009
This research / project is supported by the National Research Foundation / Ministry of Education - Research Centres of Excellence initiative
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