Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival

Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival

Cancers

10.3390/cancers14071756

http://dx.doi.org/10.3390/cancers14071756

Zi Lin Lim, Geok Hoon Lim, Peh Joo Ho, Alexis Jiaying Khng, Yen Shing Yeoh, Amanda Tse Woon Ong, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Veronique Kiak-Mien Tan, Jingmei Li, Mikael Hartman

Cancer Research, oncology

30 March 2022

Lim, Z. L., Lim, G. H., Ho, P. J., Khng, A. J., Yeoh, Y. S., Ong, A. T. W., Tan, B. K. T., Tan, E. Y., Tan, S.-M., Tan, V. K.-M., Li, J., & Hartman, M. (2022). Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival. Cancers, 14(7), 1756. https://doi.org/10.3390/cancers14071756

Physical activity (PA) is known to reduce breast cancer (BC) risk and improve patient prognosis. However, the association between pre-diagnostic PA and the aggressiveness of BC is unclear. We investigated the associations between PA, BC tumour characteristics, and survival. This retrospective observational study included 7688 BC patients from the Singapore Breast Cancer Cohort (2010–2016). PA information from the questionnaire included intensity (light/moderate/vigorous) and duration (<1 h/1–2 h/>2 h per week). A PA score (1–5) incorporating intensity and duration was calculated. Associations between PA score and tumour characteristics such as stage, histological grade, nodal and hormone receptor status were examined using multinomial regression. Moreover, 10-year overall survival was estimated using Cox regression analysis in 6572 patients after excluding patients with invalid survival data and stage IV disease. Breast tumours associated with higher PA score were more likely to be non-invasive (ORinvasive vs. non-invasive(reference) [95% CI]: 0.71 [0.58–0.87], p-trend = 0.001), of lower grade (ORpoorly vs. well differentiated(reference): 0.69 [0.52–0.93], p = 0.014), ER-positive (ORER-negative vs. ER-positive(reference): 0.94 [0.89–1.00], p-trend = 0.049), PR-positive (ORPR-negative vs. PR-positive(reference): 0.82 [0.67–0.99], p = 0.041), HER2-negative (ORHER2-negative vs. HER2-positive(reference): 1.29 [1.02–1.62], p-trend = 0.002), and less likely to be of HER2-overexpressed subtype (ORHER2-overexpressed vs. Luminal A(reference): 0.89 [0.81–0.98], p-trend = 0.018). These associations (odds ratios) were more pronounced among post-menopausal patients. A higher PA score did not improve survival. Higher levels of pre-diagnostic PA were associated with less aggressive tumours in BC patients. This illustrated another benefit of PA in addition to its known role in BC risk reduction.

Attribution 4.0 International (CC BY 4.0)

This research / project is supported by the National Research Foundation Singapore - NRF Fellowship
Grant Reference no. : NRF-NRFF2017-02

This research / project is supported by the National University of Singapore - NUS Start-up Grant
Grant Reference no. : NA

This research / project is supported by the National Medical Research Council - Clinician Scientist Award (Senior Investigator Category)
Grant Reference no. : NMRC/CSA-SI/0015/2017

This research / project is supported by the Saw Swee Hock School of Public Health - Research Programme of Research Seed Funding (Breast Cancer Prevention Program)
Grant Reference no. : NA

This research / project is supported by the Yong Loo Lin School of Medicine - Breast Cancer Screening Prevention Programme
Grant Reference no. : NA

This research / project is supported by the National University of Singapore - Asian Breast Cancer Research Fund
Grant Reference no. : NA

This research / project is supported by the National University Cancer Institute Singapore - NCIS Centre Grant
Grant Reference no. : NMRC/CG/NCIS/2010

This research / project is supported by the National University Cancer Institute Singapore - NCIS Centre Grant
Grant Reference no. : NMRC/CG/012/2013

This research / project is supported by the National University Cancer Institute Singapore - NCIS Centre Grant
Grant Reference no. : CGAug16M005

https://oar.a-star.edu.sg/communities-collections/articles/18929

2072-6694

Genome Institute of Singapore