Halogen Bonding Ionophore for Potentiometric Iodide Sensing

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Halogen Bonding Ionophore for Potentiometric Iodide Sensing
Title:
Halogen Bonding Ionophore for Potentiometric Iodide Sensing
Journal Title:
Analytical Chemistry
Keywords:
Publication Date:
12 November 2021
Citation:
Seah, G. E. K. K., Tan, A. Y. X., Neo, Z. H., Lim, J. Y. C., & Goh, S. S. (2021). Halogen Bonding Ionophore for Potentiometric Iodide Sensing. Analytical Chemistry, 93(46), 15543–15549. https://doi.org/10.1021/acs.analchem.1c03719
Abstract:
Iodide (I–) is an essential micronutrient for thyroid function. Hence, rapid and portable sensing is important for I– quantification in food and biological samples. Herein, we report the first example of a halogen bonding (XB) tripodal ionophore (XB1) which is selective for the I– anion. NMR binding studies of XB1 and its H-triazole analog HB2 with I– demonstrated the dominant influence of XB interactions between the ionophore and the I– analyte. The phase boundary model was applied to formulate iodide-selective electrodes with the ionophore XB1. The optimal electrode exhibited a near-Nernstian response of −51.9 mV per decade within a large dynamic range (10–1 to 10–6 M) and notably anti-Hofmeister selectivity for I– over thiocyanate (SCN–), enabling the in situ determination of I– in complex samples. This work establishes XB as a viable supramolecular interaction in the potentiometric sensing of anions.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the A*STAR - Career Development Fund (CDF)
Grant Reference no. : C210112021
Description:
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, copyright © 2021 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.analchem.1c03719
ISSN:
0003-2700
1520-6882
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