Tan, J., Zhao, Y., Hedrick, J. L., & Yang, Y. Y. (2021). Effects of Hydrophobicity on Antimicrobial Activity, Selectivity, and Functional Mechanism of Guanidinium‐Functionalized Polymers. Advanced Healthcare Materials, 11(7), 2100482. Portico. https://doi.org/10.1002/adhm.202100482
Abstract:
In this study, a series of guanidinium-functionalized polycarbonate random co-polymers is prepared from organocatalytic ring-opening polymerization to investigate the effect of the hydrophobic side chain (ethyl, propyl, isopropyl, benzyl, and hexyl) on their antimicrobial activity and selectivity. Although the polymers exhibit similar minimum inhibitory concentrations, the more hydrophobic polymers exhibit a faster rate of bacteria elimination. At higher percentage content (20 mol%), polymers with more hydrophobic side chains suffer from poor selectivity due to their high hemolytic activity. The highly hydrophobic co-polymer, containing the hydrophobic hexyl-functionalized cyclic carbonate, kills bacteria via a membrane-disruptive mechanism. Micelle formation leads to a lower extent of membrane disruption. This study unravels the effects of hydrophobic side chains on the activities of the polymers and their killing mechanism, providing insights into the design of new antimicrobial polymers.
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Publisher Copyright
Funding Info:
This research is supported by core funding from: Institute of Bioengineering and Bioimaging
Grant Reference no. : N.A
This project is supported by the Agency for Science, Technology and Research, Singapore under the AGS Ph.D. scholarship
Description:
This is the peer reviewed version of the following article: Tan, J., Zhao, Y., Hedrick, J. L., & Yang, Y. Y. (2021). Effects of Hydrophobicity on Antimicrobial Activity, Selectivity, and Functional Mechanism of Guanidinium‐Functionalized Polymers. Advanced Healthcare Materials, 11(7), 2100482. Portico. https://doi.org/10.1002/adhm.202100482, which has been published in final form at doi.org/10.1002/adhm.202100482. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited