Chee, P. L., Sugiarto, S., Yu, Y., Tan, Y. C., Ye, E., Kai, D., &amp; Loh, X. J. (2021). Antioxidative and Anti‐UV Lignin Carrier for Peptide Delivery. Macromolecular Chemistry and Physics, 223(2), 2100364. Portico. https://doi.org/10.1002/macp.202100364
Here, a sustainable antioxidant carrier based on lignin is developed to deliver palmitoyl tripeptide-38. The poly(lignin/polyethylene glycol (PEG)/polypropylene glycol (PPG) urethane) is polymerized by randomly coupling lignin, PEG and PPG segment blocks using hexamethylene diisocyanate as a crosslinker. The derived poly(lignin/PEG/PPG urethane) loaded with palmitoyl tripeptide-38, referred to as LM, is designed with careful considerations of both intrinsic and extrinsic causes of skin aging and a two-way approach is taken on to effectively target the problem of skin aging. Upon exposure to the ultraviolet irradiation, LM successfully protects the cells by reducing the presence of reactive oxygen species, the damage to the antioxidant enzymes, and the expression of MMP-1. Concurrently, LM also promotes the collagen production for skin repair. It is noteworthy that the collagen I content, in cells exposed to ultraviolet irradiation with LM-4 and LM-8 treatment (LM with 4 and 8 µg mL−1 palmitoyl tripeptide-38, respectively), exceeds that of the control. Overall, this work successfully demonstrates a sustainable carrier with good antioxidant properties that effectively assisted the uptake of palmitoyl tripeptide-38 by the cells.
This research is supported by core funding from: IMRE
Grant Reference no. : NA
This is the peer reviewed version of the following article: Chee, P. L., Sugiarto, S., Yu, Y., Tan, Y. C., Ye, E., Kai, D., &amp; Loh, X. J. (2021). Antioxidative and Anti‐UV Lignin Carrier for Peptide Delivery. Macromolecular Chemistry and Physics, 223(2), 2100364. Portico. https://doi.org/10.1002/macp.202100364, which has been published in final form at doi.org/10.1002/macp.202100364. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited