Wong, M. X. Y., & Chen, Q. (2022). Editorial: Humanized Mouse Models to Study Immune Responses to Human Infectious Organisms. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.860029
Abstract:
This Research Topic is a collection of 9 articles covering the latest development in humanized mice technologies in studying human infectious organisms. Ranging from bacterial infections that rapidly rot tissue and bone, to chronic viral infections with the ability to evade eradication for decades - each organism distinctly interacts and manipulates the human immune response depending on the environment. This begets the need for a model that can faithfully capture the human immune signature and the host-pathogen interaction. This Topic discusses the advances in 2 types of humanized mice: liver-humanized mice, and mice reconstituted with components of the human immune system.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the National Research Foundation - Singapore Fellowship
Grant Reference no. : NRF-NRFF2017-03
This research / project is supported by the National Research Foundation / Israel Science Foundation (ISF) - NRF-ISF joint grant
Grant Reference no. : NRF2019-NRF-ISF003-3127
This research / project is supported by the National Medical Research Council - Open Fund - Large Collaborative
Grant Reference no. : OFLCG19May-0038