Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic

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Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
Title:
Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
Other Titles:
International Journal of Molecular Sciences
Publication Date:
15 November 2021
Citation:
Chan, S. P., Lim, D. S. W., Armugam, A., Yi, G., & Zhang, Y. (2021). Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic. International Journal of Molecular Sciences, 22(22), 12315. https://doi.org/10.3390/ijms222212315
Abstract:
Surface antimicrobial materials are of interest as they can combat the critical threat of microbial contamination without contributing to issues of environmental contamination and the development drug resistance. Most nanostructured surfaces are prepared by post fabrication modifications and actively release antimicrobial agents. These properties limit the potential applications of nanostructured materials on flexible surfaces. Here, we report on an easily synthesized plastic material with inherent antimicrobial activity, demonstrating excellent microbicidal properties against common bacteria and fungus. The plastic material did not release antimicrobial components as they were anchored to the polymer chains via strong covalent bonds. Time-kill kinetics studies have shown that bactericidal effects take place when bacteria come into contact with a material for a prolonged period, resulting in the deformation and rupture of bacteria cells. A scanning probe microscopy analysis revealed soft nanostructures on the submicron scale, for which the formation is thought to occur via surface phase separation. These soft nanostructures allow for polyionic antimicrobial components to be present on the surface, where they freely interact with and kill microbes. Overall, the new green and sustainable plastic is easily synthesized and demonstrates inherent and long-lasting activity without toxic chemical leaching.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research / project is supported by the National Research Foundation - Competitive Research Program
Grant Reference no. : NRF-CRP19-2017-02

This research is supported by core funding from: A*STAR, Biomedical Research Council
Grant Reference no. :
Description:
ISSN:
1422-0067