Armugam, A., Teong, S. P., Lim, D. S. W., Chan, S. P., Yi, G., Yew, D. S., Beh, C. W., & Zhang, Y. (2021). Broad spectrum antimicrobial PDMS-based biomaterial for catheter fabrication. Biomaterials Research, 25(1). https://doi.org/10.1186/s40824-021-00235-5
Abstract:
Abstract
Background
In addition to the widespread use of antibiotics in healthcare settings, the current COVID-19 pandemic has escalated the emergence of antibiotic resistance. Nosocomial infections among hospitalized patients is a leading site for such resistant microbial colonization due to prolonged use of invasive devices and antibiotics in therapies. Invasive medical devices, especially catheters, are prone to infections that could accelerate the development of resistant microbes. Often, catheters - particularly urinary catheters - are prone to high infection rates. Antibiotic-coated catheters can reduce infection rates and although commercially available, are limited in efficacy and choices.
Methods
Herein, a novel and facile method to fabricate PMDS-based biomaterial for the development of antimicrobial eluting catheters is presented. Silicone based organic polymer polydimethylsiloxane (PDMS) was used to prepare a biomaterial containing novel polymeric imidazolium antimicrobial compound.
Results
It was found that the PDMS-based biomaterials could eradicate microbial colonization even after 60 days in culture with continuous microbial challenge, be recycled over multiple uses, stored at room temperature for long-term usage and importantly is biocompatible.
Conclusion
The PDMS-based biomaterial displayed biocidal functionality on microbes of clinical origin, which form major threats in hospital acquired infections.
Graphical Abstract
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research is supported by core funding from: BMRC
Grant Reference no. : NA