The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity

Page view(s)
17
Checked on Nov 17, 2022
The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity
Title:
The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity
Other Titles:
The Journal of Clinical Endocrinology & Metabolism
Publication Date:
12 February 2022
Citation:
Tan, K. M.-L., Tint, M.-T., Kothandaraman, N., Michael, N., Sadananthan, S. A., Velan, S. S., Fortier, M. V., Yap, F., Tan, K. H., Gluckman, P. D., Chong, Y.-S., Chong, M. F. F., Lee, Y. S., Godfrey, K. M., Eriksson, J. G., & Cameron-Smith, D. (2022). The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/clinem/dgac078
Abstract:
Abstract Background The kynurenine pathway generates metabolites integral to energy metabolism, neurotransmission, and immune function. Circulating kynurenine metabolites positively correlate with adiposity in children and adults, yet it is not known whether this relationship is present already at birth. In this prospective longitudinal study, we investigate the relationship between cord blood kynurenine metabolites and measures of adiposity from birth to 4.5 years. Methods Liquid chromatography-tandem mass spectrometry was used to quantify cord blood kynurenine metabolites in 812 neonates from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study. Fat percentage was measured by air displacement plyethysmography and abdominal adipose tissue compartment volumes; superficial (sSAT) and deep subcutaneous (dSAT) and internal adipose tissue were quantified by magnetic resonance imaging at early infancy in a smaller subset of neonates, and again at 4 - 4.5 years of age. Results Cord blood kynurenine metabolites appeared to be higher in female newborns, higher in Indian newborns compared to Chinese newborns, and higher in infants born by Caesarean section compared to by vaginal delivery. Kynurenine,xanthurenic acid and quinolinic acid were positively associated with birthweight, but not with subsequent weight during infancy and childhood. Quinolinic acid was positively associated with sSAT at birth. Kynurenic acid and quinolinic acid were positively associated with fat percentage at 4 years. Conclusion Several cord blood kynurenine metabolite concentrations were positively associated with birthweight, with higher kynurenic acid and quinolinic acid correlating to higher percentage body fat in childhood, suggesting these cord blood metabolites as biomarkers of early childhood adiposity.
License type:
Publisher Copyright
Funding Info:
This research / project is supported by the A*STAR - Industry Alignment Fund – Pre-positioning Programme
Grant Reference no. : H17/01/a0/005

This research / project is supported by the National Medical Research Council (NMRC) - Translational and Clinical Research (TCR) Flagship Programme
Grant Reference no. : NMRC/TCR/004-NUS/2008

This research / project is supported by the National Medical Research Council (NMRC) - Translational and Clinical Research (TCR) Flagship Programme
Grant Reference no. : NMRC/TCR/012-NUHS/2014
Description:
ISSN:
1945-7197
0021-972X
Files uploaded:

File Size Format Action
kynurenine-cord.pdf 964.47 KB PDF Request a copy