Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution

Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution

International Journal of Obesity

10.1038/s41366-021-00975-3

http://dx.doi.org/10.1038/s41366-021-00975-3

Karen Tan, Mya Thway Tint, Navin Michael, Fabian Yap, Yap Seng Chong, Kok Hian Tan, Keith M. Godfrey, Anis Larbi, Yung Seng Lee, Shiao-Yng Chan, Marielle V. Fortier, Johan G. Eriksson, Neerja Karnani

Endocrinology, Nutrition and Dietetics, Medicine (miscellaneous), Diabetes and Metabolism

04 December 2021

Tan, K., Tint, M. T., Michael, N., Yap, F., Chong, Y. S., Tan, K. H., Godfrey, K. M., Larbi, A., Lee, Y. S., Chan, S.-Y., Fortier, M. V., Eriksson, J. G., & Karnani, N. (2021). Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution. International Journal of Obesity, 46(3), 637–645. https://doi.org/10.1038/s41366-021-00975-3

Abstract Background Cord blood leptin and adiponectin are adipokines known to be associated with birth weight and overall infant adiposity. However, few studies have investigated their associations with abdominal adiposity in neonates. We examined maternal factors associated with cord blood leptin and adiponectin, and the association of these adipokines with neonatal adiposity and abdominal fat distribution measured by magnetic resonance imaging (MRI) in an Asian mother–offspring cohort. Methods Growing Up in Singapore Towards healthy Outcomes (GUSTO), is a prospective mother–offspring birth cohort study in Singapore. Cord blood plasma leptin and adiponectin concentrations were measured using Luminex and Enzyme-Linked Immunosorbent Assay respectively in 816 infants. A total of 271 neonates underwent MRI within the first 2-weeks after delivery. Abdominal superficial (sSAT), deep subcutaneous (dSAT), and intra-abdominal (IAT) adipose tissue compartment volumes were quantified from MRI images. Multivariable regression analyses were performed. Results Indian or Malay ethnicity, female sex, and gestational age were positively associated with cord blood leptin and adiponectin concentrations. Maternal gestational diabetes (GDM) positively associated with cord blood leptin concentrations but inversely associated with cord blood adiponectin concentrations. Maternal pre-pregnancy body mass index (BMI) showed a positive relationship with cord blood leptin but not with adiponectin concentrations. Each SD increase in cord blood leptin was associated with higher neonatal sSAT, dSAT and IAT; differences in SD (95% CI): 0.258 (0.142, 0.374), 0.386 (0.254, 0.517) and 0.250 (0.118, 0.383), respectively. Similarly, each SD increase in cord blood adiponectin was associated with higher neonatal sSAT and dSAT; differences in SD (95% CI): 0.185 (0.096, 0.274) and 0.173 (0.067, 0.278), respectively. The association between cord blood adiponectin and neonatal adiposity was observed in neonates of obese mothers only. Conclusions Cord blood leptin and adiponectin concentrations were associated with ethnicity, maternal BMI and GDM, sex and gestational age. Both adipokines showed positive association with neonatal abdominal adiposity.

Attribution 4.0 International (CC BY 4.0)

This research / project is supported by the National Medical Research Council (NMRC) - Translational and Clinical Research (TCR) Flagship Programme
Grant Reference no. : NMRC/TCR/004-NUS/2008

This research / project is supported by the National Medical Research Council (NMRC) - Translational and Clinical Research (TCR) Flagship Programme
Grant Reference no. : NMRC/TCR/012-NUHS/2014

This research / project is supported by the A*STAR - Industry Alignment Fund Pre-Positioning Programme
Grant Reference no. : H17/01/a0/005

https://oar.a-star.edu.sg/communities-collections/articles/18199

1476-5497
0307-0565

Singapore Institute for Clinical Sciences

https://doi.org/10.1038/s41366-021-00975-3
https://www.nature.com/articles/s41366-021-00975-3.pdf