Jackson, A. W.; Chennamaneni, L. R.; Mothe, S. R.; Thoniyot, P., A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers. Chemical Communications 2020, 56 (68), 9838-9841.
Abstract:
Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid N-hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust and straightforward route to main-chain degradable polymeric nanoparticles in the sub-30 nm size range.
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Publisher Copyright
Funding Info:
This research / project is supported by the Agency for Science, Technology and Research (A*STAR) - Industry Alignment Fund - Pre-Positioning Programme (IAF-PP)
Grant Reference no. : A1786a0025