Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer

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Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer
Title:
Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer
Journal Title:
Cancers
Publication Date:
15 March 2021
Citation:
Wu, Z., Lee, Y. F., Yeo, X. H., Loo, S. Y., & Tam, W. L. (2021). Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer. Cancers, 13(6), 1316. doi:10.3390/cancers13061316
Abstract:
Cancer metabolism is a hallmark of cancer. Metabolic plasticity defines the ability of cancer cells to reprogram a plethora of metabolic pathways to meet unique energetic needs during the various steps of disease progression. Cell state transitions are phenotypic adaptations which confer distinct advantages that help cancer cells overcome progression hurdles, that include tumor initiation, expansive growth, resistance to therapy, metastasis, colonization, and relapse. It is increasingly appreciated that cancer cells need to appropriately reprogram their cellular metabolism in a timely manner to support the changes associated with new phenotypic cell states. We discuss metabolic alterations that may be adopted by cancer cells in relation to the maintenance of cancer stemness, activation of the epithelial–mesenchymal transition program for facilitating metastasis, and the acquisition of drug resistance. While such metabolic plasticity is harnessed by cancer cells for survival, their dependence and addiction towards certain metabolic pathways also present therapeutic opportunities that may be exploited.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research was funded by National Medical Research Council, Singapore (OFIRG17may061, OFIRG19nov-0106, OFYIRG18May-0025, NMRC/CIRG/1470/2017; NMRC/OFLCG/002-2018), National Research Foundation, Singapore (NRF-NRFF2015-04, NRF-CRP22-2019-0003, NRF-CRP23- 2019-0004), National Cancer Institute Singapore Yong Siew Yoon Research Grant (R-713-002-204-720) Core Funding from Singapore Ministry of Education under its Research Centers of Excellence initiative Core Funding from Genome Institute of Singapore (A*STAR)
Description:
NA
ISSN:
2072-6694
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