Shi, H., Chi, H., Luo, Z., Jiang, L., Loh, X. J., He, C., & Li, Z. (2019). Self-Healable, Fast Responsive Poly(ω-Pentadecalactone) Thermogelling System for Effective Liver Cancer Therapy. Frontiers in Chemistry, 7. doi:10.3389/fchem.2019.00683
Abstract:
A polyurethane based thermogelling system comprising poly(&-pentadecalactone)
(PPDL), poly(ethylene glycol) (PEG), and poly(propylene glycol) (PPG), termed as PDEP,
was synthesized. The incorporation of PPDL lowers critical micelle concentration (CMC)
as well as critical gelation concentration (CGC) of the novel copolymers compared
to commercial Pluronic® F127. The thermogels showed excellent thermal stability at
high temperature up to 80◦C, fast response to temperature change in a time frame of
less than second, as well as remarkable self-healing properties after being broken at
high strain. In vitro drug release studies using docetaxel (DTX) and cell uptake studies
using doxorubicin (DOX) show high potential of the hydrogel as drug reservoir for
sustainable release profile of payloads, while the in vivo anti-tumor evaluation using mice
model of hepatocellular carcinoma further demonstrated the significant inhibition on the
growth of tumor. Together with its excellent biocompatibility in different organs, the novel
PDPE thermogelling copolymers reported in this work could potentially be utilized as in
situ-forming hydrogels for liver cancer therapy.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This research is supported by core funding from: IMRE
Grant Reference no. : This research is supported by the Institute of Materials Research and Engineering, A*STAR. Grant number is not applicable.