AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy

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AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy
Title:
AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy
Journal Title:
Macromolecular Bioscience
Publication Date:
19 April 2021
Citation:
Fan, X., Luo, Z., Ye, E., You, M., Liu, M., Yun, Y., Loh, X.J., Wu, Y.-L. and Li, Z. (2021), AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy. Macromol. Biosci., 21: 2100062. https://doi.org/10.1002/mabi.202100062
Abstract:
A unique platform for combined photothermal and chemotherapy using PLA stereocomplex (PLA SC) micelles-induced hybrid gold nanocarriers is designed. The PLA SC micelles, made from the self-assembly of poly(ethylene glycol)-block-poly(l-lactide) (PEG-PLLA) and poly(2-(dimethylamino) ethyl methacrylate)-block-poly(d-lactide) (PDMAEMA-PDLA), for the first time are used as a template to fabricate the hybrid PLA SC@Au core–shell nanocarriers, in which the anticancer drugs are encapsulated within the core, while the Au nanoparticles are tethered in the shell via the in situ reduction of AuCl4− by PDMAEMA. The obtained PLA SC@Au hybrid nanocarriers exhibit low toxicity and remarkable photothermal effect. Upon near-infrared laser irradiation, the on-site photothermal therapy can further induce an accelerated drug release from the hybrid nanocarrier reservoir via hyperthermia heating of the nanocarriers, thus leading to a synergistic photothermal and chemotherapy toward a significantly improved efficacy in tumor shrinkage. The as-designed PLA SC@Au hybrid nanocarriers, with their biocompatible compositions, dual-drug delivery characteristics, and combined photothermal/chemotherapy, show high potential as a novel platform for cancer treatment.
License type:
Publisher Copyright
Funding Info:
This research is supported by core funding from: This research is supported by the Institute of Materials Research and Engineering, A*STAR.
Grant Reference no. : Grant number is not applicable.
Description:
This is the peer reviewed version of the following article: Fan, X., Luo, Z., Ye, E., You, M., Liu, M., Yun, Y., Loh, X.J., Wu, Y.-L. and Li, Z. (2021), AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy. Macromol. Biosci., 21: 2100062. https://doi.org/10.1002/mabi.202100062, which has been published in final form at https://doi.org/10.1002/mabi.202100062. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
ISSN:
1616-5187
1616-5195
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