Generation of Micronuclei and Detection of Chromosome Pulverization

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Generation of Micronuclei and Detection of Chromosome Pulverization
Title:
Generation of Micronuclei and Detection of Chromosome Pulverization
Journal Title:
Methods in Molecular Biology
Keywords:
Publication Date:
22 March 2018
Citation:
Luijten M.N.H., Lee J.X.T., Chen S., Crasta K.C. (2018) Generation of Micronuclei and Detection of Chromosome Pulverization. In: Pellestor F. (eds) Chromothripsis. Methods in Molecular Biology, vol 1769. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7780-2_12
Abstract:
Lagging chromosomes that arise after chromosome mis-segregation during cell division can be encapsulated within small structures known as micronuclei. A link between whole-chromosome mis-segregation and chromothripsis has been demonstrated via micronuclear chromosome pulverization. Here, we describe methods to efficiently generate micronuclei and examine downstream cell fates, specifically with regard to DNA damage and chromosome pulverization.
License type:
Publisher Copyright
Funding Info:
There was no specific funding for the research done
Description:
ISBN:
978-1-4939-7779-6
978-1-4939-7780-2
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