Humanized Mice as Unique Tools for Human-Specific Studies

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Humanized Mice as Unique Tools for Human-Specific Studies
Humanized Mice as Unique Tools for Human-Specific Studies
Journal Title:
Archivum Immunologiae et Therapiae Experimentalis
Publication Date:
07 February 2018
Yong, K. S. M., Her, Z., & Chen, Q. (2018). Humanized Mice as Unique Tools for Human-Specific Studies. Archivum Immunologiae et Therapiae Experimentalis, 66(4), 245–266. doi:10.1007/s00005-018-0506-x
With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, “humanized” mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans. Currently, literature is rife with descriptions of novel and innovative humanized mouse models that hold a significant promise to become a panacea for drug innovations to treat and control conditions such as infectious disease and cancer. This review will focus on the background of humanized mice, diseases, and human-specific therapeutics tested on this platform as well as solutions to improve humanized mice for future clinical use.
License type:
Attribution 4.0 International (CC BY 4.0)
Funding Info:
This work was supported by the following grants: National Research Foundation Fellowship Singapore NRF-NRFF2017-03 (Q. Chen.), Eradication of HBV TCR Program: NMRC/TCR/014-NUHS/2015, National Medical Research Council, Singapore (Q. Chen) and A*STAR graduate scholarship from Agency for Science, Technology and Research (A*STAR), Singapore (K.S.M. Yong).
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