Funding Info:
We thank Sir Lambert Cornelias Bronsveld and Lady Bronsveld-Ngo Kim Lian for philanthropic support (B.T. Teh). This work was supported by the Singapore National Medical Research Council [NMRC/STaR/0006/2009 (B.T. Teh), NMRC/STaR/0024/2014 (B.T. Teh), NMRC/CG/012/2013 (B.T. Teh), NMRC/CIRG/1422/2015 (S.G. Rozen), and NMRC/STaR/0026/2015 (P. Tan)], Genome Institute of Singapore (P. Tan), Duke-NUS Medical School (P. Tan, S.G. Rozen), National University of Singapore, the National Research Foundation Singapore, Singapore Ministry of Education under the Research Centres of Excellence initiative (P. Tan), National University Cancer Institute, Singapore (NCIS) Centre Grant NR 13NMR 111OM (P. Tan), the Japan Agency for Medical Research and Development (Practical Research for Innovative Cancer Control, 15ck0106094h0002; T. Shibata), National Cancer Center Research and Development Funds (26-A-5; T. Shibata), Italian Cancer Genome Project (FIRB RBAP10AHJB; A. Scarpa), Associazione Italiana Ricerca sul Cancro (n. 12182; A. Scarpa), Italian Ministry of University Health (FIMP CUP_J33G13000210001; A. Scarpa), the NCI of the NIH (P01CA142538; R. Gordan), and the National Natural Science Foundation of China (NSFC81372825; J. Lai). This study was performed as part of the International Cancer Genome Consortium (ICGC). We thank the Duke-NUS Genome Biology Facility for methylation and gene expression assays, the Genome Institute of Singapore Population Genetics facility for SNP arrays, and the Cytogenetics Laboratory, Department of Molecular Pathology, Singapore General Hospital for FISH analysis. We thank D. Jefferson (New England Medical Center, Tufts University) for H69 cells. We also thank the SingHealth Tissue Repository, Dr. Catherine Guettier, and Dr. Jean-Charles Duclos-Vallée (DHU Hepatinov, Hôpital Paul Brousse, AP-HP, Villejuif, France) for tissue samples.This work was supported by the Singapore National Medical Research Council (NMRC/STaR/0006/2009, NMRC/STaR/0024/2014, NMRC/CG/012/2013, NMRC/CIRG/1422/2015, and NMRC/STaR/0026/2015), Genome Institute of Singapore, Duke-NUS Medical School, National University of Singapore, the National Research Foundation Singapore, Singapore Ministry of Education under the Research Centres of Excellence initiative, Japan Agency for Medical Research and Development (Practical Research for Innovative Cancer Control, 15ck0106094h0002), National Cancer Center Research and Development Funds (26-A-5), Italian Cancer Genome Project (FIRB RBAP10AHJB), Associazione Italiana Ricerca sul Cancro (n. 12182), Italian Ministry of University Health (FIMP CUP_J33G13000210001) and National Natural Science Foundation of China (NSFC81372825). We thank Sir Lambert Cornelias Bronsveld and Lady Bronsveld-Ngo Kim Lian for philanthropic support.