Funding Info:
This work was supported by Biomedical Research Council Young Investigator Grant 1510851024, National Natural Science Foundation of China 61661146004, National Research Foundation grant NRF2016NRF-NSFC001-057, and National Medical Research Council grants NMRC/STaR/0026/2015, NMRC/STAR/0024/2014, NMRC/CIRG/1402/2014, and NMRC/CBRG/069/2014. Core funding was provided by the Genome Institute of Singapore and Institute of Molecular and Cell Biology under the Agency for Science, Technology and Research, and Duke-NUS Medical School. Other sources of support include the Cancer Science Institute of Singapore, NUS, funded by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative, and Biomedical Research Council Strategic Positioning Fund 2012/001. J.R. Hughes was supported by a Wellcome Trust Strategic Award (reference 106130/Z/14/Z) and Medical Research Council (MRC) Core funding. J.O.J. Davies was funded by a Wellcome Trust Clinical Research Training Fellowship (ref 098931/Z/12/Z). We thank Hui Hoon Chua, Angie Tan, and Liang Kai Koh for their administrative support. We thank the Sequencing and Scientific Computing teams at the Genome Institute of Singapore for sequencing services and data management capabilities, and the Duke-NUS Genome Biology Facility for sequencing services. We thank the Advanced Molecular Pathology Laboratory of the Institute of Molecular and Cell Biology for pathology evaluation. Xiaosai Yao dedicates this paper to the memory of her mother, Tan Limin, for her unconditional love and support. This work was supported by core funding from the Genome Institute of Singapore and Institute of Molecular and Cell Biology under the Agency for Science, Technology and Research, Biomedical Research Council Young Investigator Grant 1510851024, National Medical Research Council grants NMRC/STaR/0026/2015, NMRC/CIRG/1402/2014 and CBRG/069/2014, and National Research Foundation grant NRF2016NRF-NSFC001-057. Other sources of support include the Cancer Science Institute of Singapore, NUS, funded by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative. J.R.H. was supported by a Wellcome Trust Strategic Award (reference 106130/Z/14/Z) and Medical Research Council (MRC) Core funding. J.O.J.D. was funded by Wellcome Trust Clinical Research Training Fellowship (ref 098931/Z/12/Z).