This work was supported by Singapore NRF fellowship (NRF-2011NRF-NRFF 001-025), Tanoto Initiative in Diabetes Research to L.S., National Medical Research Council’s Cooperative Basic Research Grant (CBRG; NMRC/CBRG/0070/2014 and NMRC/CBRG/0101/2016), Open Fund-Individual Research (OF-IRG) Grant (NMRC/OFIRG/0062/2017), and Ministry of Education (MOE) Tier2 grant (MOE2017-T2-2-009). This work was supported by the RNA Biology Center at CSI Singapore, NUS, from funding by the Singapore Ministry of Education’s Tier 3 grants, grant number MOE2014-T3-1-006. This work was also supported by the Recruitment Program for Young Professionals (C.D.), Zhejiang Key Subject of Medical Science (C.D.), National Natural Science Foundation of China (81700770), and Zhejiang Provincial Natural Science Foundation of China (LY18C060006).