Role of the β Common (βc) Family of Cytokines in Health and Disease

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Role of the β Common (βc) Family of Cytokines in Health and Disease
Role of the β Common (βc) Family of Cytokines in Health and Disease
Journal Title:
Cold Spring Harbor Perspectives in Biology
Publication Date:
17 July 2017
Splenic Innate B1 B Cell Plasmablasts Produce Sustained Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Cytokines during Murine Malaria Infections Infect. Immun. December 1, 2019;87:e00482-19
The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the βc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the βc cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.
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Funding Info:
This work is supported by grants from the National Health and Medical Research Council of Australia (NHMRC), the Australian Cancer Research Foundation, the Leukemia Foundation of Australia, and CSL Limited, aswell as funding from Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme. This research is supported by core funding from Institute of Molecular and Cell Biology.
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