Mak, A., Thornhill, S.I., Lee, H.Y. et al. Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus. Clin Rheumatol 37, 811–816 (2018). https://doi.org/10.1007/s10067-017-3698-2
The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE). Since previous investigations on CD244 expression have focussed on NK and T cells, the aim of this study was to evaluate the surface expression of major SLAMF members across monocytes and polymorphonuclear cells in an Asian SLE cohort and explore their potential associations with SLE-related disease activity and autoantibodies. Thirty-nine SLE patients and twenty-nine healthy controls (HC) were evaluated for the expression of CD150, CD84, CD229, CD48, CD244, CD352 and CD319. We determined a significantly lower expression of CD244 on monocytes in SLE patients compared to HC. Furthermore, monocyte CD244 expression was negatively associated with several serum autoantibody titres. Our findings suggest that this molecule plays an important role in immune tolerance mechanisms and should be investigated further.
This study was supported by funding from an A*STAR-JJSI Joint Grant 1218226002 and core funding from the Singapore Immunology Network (SIgN) to AMF and the Institute for Molecular and Cell Biology to JEC at the Agency for Science, Technology and Research (A*STAR), Singapore. This study was supported by funding from an A*STAR-JJSI Joint Grant 1218226002 and core funding from the Singapore Immunology Network (SIgN) to Dr Anna-Marie Fairhurst’s lab and the Institute for Molecular and Cell Biology to JEC at the Agency for Science, Technology and Research (A*STAR), Singapore.