Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs

Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs
Title:
Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs
Other Titles:
Drug Discovery Today
Keywords:
Publication Date:
25 January 2016
Citation:
Zhang P, Woen S, Wang T, et al. Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs. Drug Discov Today. 2016;21(5):740‐765. doi:10.1016/j.drudis.2016.01.006
Abstract:
Glycosylation of therapeutic proteins has a profound impact on their safety and efficacy. Many factors shape the glycosylation of biotherapeutics, ranging from expression systems and cell culture processes to downstream purification strategies. Various analytical technologies have been developed to address questions concerning different aspects of glycosylation. Informatics tools are also crucial for a systematic understanding of the glycosylation processes. Hence, an integrated approach is required to harness glycosylation for the production of optimal and consistent glycoprotein-based therapeutic drugs. Here, we review the latest developments and challenges in glycosylation analysis and control in the context of bioprocessing monoclonal antibodies.
License type:
http://creativecommons.org/licenses/by/4.0/
Funding Info:
This research / project is supported by the A*STAR Joint Council Office, under its HighGlycoART funding programme ( Award 1355g00086) This research / project is supported by the A*STAR Biomedical Research Council, under its GlycoSing funding programme (Award SPF2013/001)
Description:
Please find the link to the article at the publisher's URL: https://doi.org/10.1016/j.drudis.2016.01.006 Citation: Zhang P, Woen S, Wang T, et al. Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs. Drug Discov Today. 2016;21(5):740‐765. doi:10.1016/j.drudis.2016.01.006
ISSN:
1359-6446
1878-5832
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