We deeply appreciate the support and encouragement provided by all members of the Kaldis lab. We thank June Wang, Vithya Anantaraja, and Chloe Sim for help with animal care, Sheena Wee and Jayantha Gunaratne for mass spectrometry, Jiaxuan Chen for ChIP-sequencing, Calista K. L. Ng, Ralf Jauch, and Prasanna R. Kolatkar for EMSA, Araki Marito for the in vitro ubiquitylation assay, Xavier Bisteau for help with the preparation of the final figures, and Wei Theng Poh for chromatin extraction. We acknowledge the technical expertise provided by the Advanced Molecular Pathology Laboratory at IMCB.
The authors contributed to this article as follows: S.L., conception and design, collection and/or assembly of data, data analysis and interpretation, and manuscript writing; A.B., I.A., and L.W.S., data collection, data analysis, and interpretation for ChIP-sequencing; J.A., S.B.A., and F.C., data collection, data analysis and interpretation, and manuscript writing for in vivo mouse brain electroporation; C.F.C., discussion; P.K., conception and design, data analysis and interpretation, manuscript writing, financial support, and direction of the study.
This work was supported by the Biomedical Research Council of A*STAR (Agency for Science, Technology and Research), Singapore.
We declare that we have no competing interests.
All data needed to evaluate the conclusions in this paper are presented here. Additional data related to this work may be requested from the authors.