Revalorizing Lignocellulose for the Production of Natural Pharmaceuticals and other High Value Bioproducts

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Revalorizing Lignocellulose for the Production of Natural Pharmaceuticals and other High Value Bioproducts
Title:
Revalorizing Lignocellulose for the Production of Natural Pharmaceuticals and other High Value Bioproducts
Journal Title:
Current Medicinal Chemistry
Publication Date:
07 May 2021
Citation:
Congqiang Zhang, Heng-Phon Too. Revalorizing Lignocellulose for the Production of Natural Pharmaceuticals and Other High Value Bioproducts. Current Medicinal Chemistry. Volume 26 , Issue 14 , 2019
Abstract:
Lignocellulose is the most abundant renewable natural resource on earth and has been successfully used for the production of biofuels. A significant challenge is to develop cost-effective, environmentally friendly and efficient processes for the conversion of lignocellulose materials into suitable substrates for biotransformation. A number of approaches have been explored to convert lignocelluose into sugars, e.g. combining chemical pretreatment and enzymatic hydrolysis. In nature, there are organisms that can transform the complex lignocelluose efficiently, such as wood-degrading fungi (brown rot and white rot fungi), bacteria (e.g. Clostridium thermocellum), arthropods (e.g. termite) and certain animals (e.g. ruminant). Here, we highlight recent case studies of the natural degraders and the mechanisms involved, providing new utilities in biotechnology. The sugars produced from such biotransformations can be used in metabolic engineering and synthetic biology for the complete biosynthesis of natural medicine. The unique opportunities in using lignocelluose directly to produce natural drug molecules with either using mushroom and/or 'industrial workhorse' organisms (Escherichia Coli and Saccharomyces Cerevisiae) will be discussed.
License type:
Funding Info:
This research is supported by the BioTransformation Innovation Platform, A*STAR, under its IAFPP programme (award no H1701a0006)
Description:
The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/0929867324666170912095755.
ISBN:

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