Relation of infant dietary patterns to allergic outcomes in early childhood

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Relation of infant dietary patterns to allergic outcomes in early childhood
Title:
Relation of infant dietary patterns to allergic outcomes in early childhood
Journal Title:
Pediatric Allergy and Immunology
Publication Date:
28 April 2017
Citation:
Loo, E. X. L., Sim, J. Z. T., Toh, J. Y., Goh, A., Teoh, O. H., Chan, Y. H., … Shek, L. P. (2017). Relation of infant dietary patterns to allergic outcomes in early childhood. Pediatric Allergy and Immunology, 28(5), 490–495. doi:10.1111/pai.12727
Abstract:
Allergic disorders result from the complex interplay between genetic predisposition and environmental influences. According to the Developmental Origins of Health and Disease hypothesis, environmental pressures at critical or early periods of development can evoke persisting changes in gene regulation and expression (1), affecting disease development. Infant nutrition is a major environmental influence in early life as the immature gut is exposed to a variety of food proteins. However, results from studies examining the early introduction of allergenic food and allergic outcomes have been conflicting. In addition, the current literature, describing associations between different types of diet or nutrients and allergic outcomes, consists mainly of either cross-sectional studies or case-control studies that examine children during pre-school or school-going ages (2). Moreover, studies that have examined the contribution of infant nutrition to the development of paediatric allergic outcomes in a prospective birth cohort setting in Asia have mainly focused on breastfeeding and its effects on allergic diseases (3). In this study, we analysed the influence of infant dietary patterns in the first year of life on allergic outcomes (allergen sensitization, eczema, rhinitis and wheeze with use of nebuliser) until the age of 5 years in the Growing Up in Singapore towards healthy Outcomes (GUSTO) mother-offspring cohort, potentially offering insights into the effects of infant diet on allergic outcomes in early life.
License type:
Publisher Copyright
Funding Info:
This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore- NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. This work is also supported by the National Medical Research Council, NMRC/CSA/022/2010 and NRF370062-HUJ-NUS (Project 10). Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. KMG is funded by the NIHR through the NIHR Southampton Biomedical Research Centre.
Description:
This is the peer reviewed version of the following article: Loo, E. X. L., Sim, J. Z. T., Toh, J. Y., Goh, A., Teoh, O. H., Chan, Y. H., … Shek, L. P. (2017). Relation of infant dietary patterns to allergic outcomes in early childhood. Pediatric Allergy and Immunology, 28(5), 490–495. doi:10.1111/pai.12727, which has been published in final form at http://dx.doi.org/10.1111/pai.12727. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
ISSN:
0905-6157
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