Objectives: The increasing prevalence of advanced maternal age (AMA) coupled with poor sleep quality
among pregnant women makes it important to study their association with perinatal outcomes. However,
little is known about the interaction of AMA and maternal antenatal sleep on perinatal outcomes. Here, we
examined whether associations between AMA and perinatal outcomes are modified by antenatal sleep
quality.
Participants: Data were collected from 446 women, with a singleton pregnancy and no pregnancy complications, who participated in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study.
Measurements: Participants completed the Pittsburgh Sleep Quality Index (PSQI) at 26-28 weeks gestation
and had perinatal outcome data collected upon delivery. Interactions between AMA and maternal sleep
quality on perinatal outcomes were investigated and where significant, analyses were further stratified
by maternal age. All analyses were adjusted for maternal BMI at 26-28 weeks gestation, ethnicity, and
maternal education.
Results: Neonates of mothers of AMA and poor sleep quality (PSQI score >5) had increased odds of stay in
the neonatal intensive care unit (adjusted odds ratio¼ 3.53, 95% CI: 1.21 to 10.27) and shorter birth length
(adjusted mean difference¼ 1.05 cm, 95% CI: 1.82 to 0.20), as compared with women of AMA and good
sleep quality (PSQI score 5). In women
License type:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Funding Info:
This research is supported by the Singapore National
Research Foundation under its Translational and Clinical
Research (TCR) Flagship Programme and administered by the
Singapore Ministry of Health’s National Medical Research Council
(NMRC), Singapore - NMRC/TCR/004-NUS/2008; NMRC/TCR/
012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore.
Description:
Open Access article: https://www.sciencedirect.com/science/article/pii/S2352721819302232?via%3Dihub