Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians

Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians
Title:
Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians
Other Titles:
European Journal of Clinical Investigation
Publication Date:
08 February 2019
Citation:
Chan Z, Ding C, Chooi YC, et al. Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians. Eur J Clin Invest. 2019;49(5):e13079. doi:10.1111/eci.13079
Abstract:
Background: The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in subjects from the nonobese Asians is not known. Materials and methods: We conducted a cross-sectional study and measured insulin sensitivity (M value; 4-hour hyperinsulinaemic-euglycaemic clamp), insulin secretion rate (3-hour mixed meal tolerance test with oral minimal modelling), percent body fat, visceral adipose tissue, intramyocellular and intrahepatic lipid contents (magnetic resonance imaging and spectroscopy), cardiorespiratory fitness (VO2 max; graded exercise test) and habitual physical activity (short International Physical Activity Questionnaire) in 60 healthy nonobese Asian subjects (BMI = 21.9 ± 1.7 kg/m2 , age = 41.8 ± 13.4 years). Results: M was inversely associated with percent body fat (r = -0.460, P < 0.001), visceral fat (r = -0.623, P < 0.001) and liver fat (r = -0.601, P < 0.001), whereas insulin secretion correlated positively with these adiposity indices (percent body fat: r = 0.303, P = 0.018; visceral fat: r = 0.409, P = 0.010; hepatic fat: r = 0.393, P = 0.002). VO2 max correlated negatively with insulin secretion rate (r = -0.420, P < 0.001) and positively with M (r = 0.658, P < 0.001). The amount of vigorous physical activity was positively associated with VO2 max (r = 0.682, P < 0.001). Multiple stepwise linear regression analyses indicated that VO2 max, age, and IHTG or VAT were independent determinants of insulin sensitivity and secretion (adjusted R2 = 69% and 33%, respectively, P < 0.001). Conclusions: Increased ectopic fat deposition is associated with reduced insulin sensitivity and increased insulin secretion in healthy nonobese Asians. Poor cardiorespiratory fitness, likely due to inadequate participation in vigorous exercise, is strongly related to suboptimal metabolic function. Interventions to encourage engagement in physical activity may thus be important for improving metabolic health in nonobese Asians.
License type:
PublisherCopyrights
Funding Info:
This study was supported by award BMSI/16‐07803C‐R20H from the Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore
Description:
ISSN:
0014-2972
1365-2362
Files uploaded:

File Size Format Action
eci13079.pdf 1.94 MB PDF Open