Polyphenol-rich Curry Made With Mixed Spices and Vegetables Increases Postprandial Plasma GLP-1 Concentration in a Dose-Dependent Manner

Polyphenol-rich Curry Made With Mixed Spices and Vegetables Increases Postprandial Plasma GLP-1 Concentration in a Dose-Dependent Manner
Title:
Polyphenol-rich Curry Made With Mixed Spices and Vegetables Increases Postprandial Plasma GLP-1 Concentration in a Dose-Dependent Manner
Other Titles:
European Journal of Clinical Nutrition
Keywords:
Publication Date:
28 December 2017
Citation:
Haldar, S., Chia, S. C., & Henry, C. J. (2018). Polyphenol-rich curry made with mixed spices and vegetables increases postprandial plasma GLP-1 concentration in a dose-dependent manner. European journal of clinical nutrition, 72(2), 297–300. https://doi.org/10.1038/s41430-017-0069-7
Abstract:
Glucagon-like peptide-1 (GLP-1) plays an important role in glucose homeostasis. Evidence is emerging that dietary bioactive phytochemicals such as polyphenols can increase GLP-1 concentration in vivo. Spices are rich in polyphenols and have oro-sensory properties, both of which can increase GLP-1 secretion. We therefore investigated the effects of mixed spices intake on postprandial GLP-1 concentration. Using a randomised, controlled, dose-response crossover trial in 20 young, healthy, Chinese men, volunteers were served white rice with 3 doses of curry made with mixed spices and vegetables. These test meals were isocaloric and macronutrient matched. Plasma total GLP-1 concentrations were measured before (baseline) and for up to 3 h after the consumption of test meals. We found a significant dose dependent increase in total AUC of plasma GLP-1 concentrations, adjusted for baseline, with increasing mixed spice doses [adjusted mean (±SEM) of 10568.3 ± 1267.9, 12391.8 ± 1333.94, and 13905.1 ± 1267.6 pg ml-1.min for Dose 0 Control, Dose 1 Curry and Dose 2 Curry respectively (p = 0.019)]. Consumption of polyphenol rich mixed spices and vegetables can therefore increase in vivo GLP-1 concentration.
License type:
PublisherCopyrights
Funding Info:
This project was funded by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore.
Description:
ISSN:
0954-3007
1476-5640
Files uploaded:

File Size Format Action
article-file-2017ejcn0873r-combined.pdf 914.71 KB PDF Open